三阴性乳腺癌的超声表现及其BRCA1蛋白表达情况  

The ultrasonic manifestation and the expression level of BRCA1 protein in triple-negative breast cancer

作　　者：孙欣欣 夏炳兰[1] SUN Xinxin;XIA Binglan(Department of Ultrasonography,Northern Jiangsu Peoples Hospital,Yangzhou,Jiangsu 225001,China)

机构地区：[1]江苏省苏北人民医院超声科

出　　处：《徐州医科大学学报》2019年第4期298-301,共4页Journal of Xuzhou Medical University

摘　　要：目的探讨三阴性乳腺癌的超声图像表现及其BRCA1蛋白表达情况。方法回顾性分析经病理证实为乳腺癌的200例患者的临床资料,根据术后免疫组化评价雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子受体2(HER2)的表达情况将200例患者分为三阴性乳腺癌(TNBC)组78例及非三阴性乳腺癌(非TNBC)组122例,分析比较2组的临床与病理特征、超声图像表现及BRCA1蛋白表达情况。结果TNBC组超声图像表现为肿瘤周边光整、无明显毛刺征的比例显著高于非TNBC组(P<0.05)。TNBC组淋巴结转移率高于非TNBC组(P<0.05)。TNBC组肿瘤微钙化发生率明显低于非TNBC组(P<0.05)。TNBC组的BRCA1蛋白阳性率低于非TNBC(P<0.05)。结论TNBC常见的超声表现为淋巴结转移率高,肿瘤边缘光整、少毛刺征及少微钙化等。BRCA1蛋白在TNBC中低表达。Objective To investigate the ultrasonic fidings and the expression of BRCA1 protein in triple-negative breast cancer(TNBC).Methods The clinical data of 200 patients with breast cancer confirmed by pathology were retrospectively analyzed.The patients were divided into TNBC group and non-TNBC group according to the evaluation of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor 2(HER2).The clinical and pathological features,ultrasonic findings and BRCA1 protein expression were analyzed and compared between the two groups.Results Ultrasound images showed that the proportions of neat peripheral areas and no obvious burr sign were significantly higher in the TNBC group than those in the non-TNBC group(P<0.05);the lymph node metastasis rate of the TNBC group was higher than that of the non-TNBC group(P<0.05).The incidence of microcalcification in the TNBC group was significantly lower than that of the non-TNBC group(P<0.05).The positive rate of BRCA1 protein in the TNBC group was lower than that of the non-TNBC group(P<0.05).Conclusions The common ultrasonic features of TNBC are high lymph node metastasis rate,smooth tumor margin,less burr sign and less microcalcification.The expression of BRCA1 protein is low in TNBC.

关 键 词：三阴性乳腺癌 超声图像 BRCA1蛋白 

分 类 号：R739.9[医药卫生—肿瘤]