病毒感染相关性胃癌的研究现状和进展  

Current status and progress in the research for viral nfection-associated gastric cancer

作　　者：张心阳 郦源 张子臻[2] 赵恩昊[2] Zhang Xinyang;Li Yuan;Zhang Zizhen;Zhao Enhao(Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China;Department of Gastrointestinal Surgery, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200127, China)

机构地区：[1]上海交通大学医学院,200025 [2]上海交通大学医学院附属仁济医院胃肠外科,200127

出　　处：《国际外科学杂志》2019年第4期254-261,共8页International Journal of Surgery

基　　金：国家大学生创新创业训练计划(1117019).

摘　　要：病毒感染与胃癌的发生、发展密切相关,其中以EB病毒阳性为特征的EB病毒相关胃癌已被列为一种独特胃癌分子亚型,其流行病学、分子机制、临床和组织学特征得到了较为详尽的研究,同时溶瘤病毒展现了病毒对肿瘤的抑制作用,其靶向及杀伤肿瘤细胞的能力在部分晚期癌症的治疗中得到应用。本文将围绕与胃癌关系较为密切的几种病毒,并就其在肿瘤发生、发展中发挥的作用,及溶瘤病毒抗癌机制与联合疗法的最新进展进行综述。Gastric cancer is one of the malignant tumors with high morbidity and high mortality in China. Research has shown that viral infection is closely related to the occurrence of gastric cancer. Epstein-Barr virus-associated gastric cancer characterized by EB virus infection has been classified as a subtype of gastric cancer, whose epidemiology, pathogenesis, clinical and histopathologic features have been studied in detail. At the same time, oncolytic viruses reveal the inhibitory effect of the virus on tumors, and their ability to target and kill tumor cells is used in the treatment of some advanced cancers. This article will review the research advances about relevance to gastric cancer of several viruses that have been reported and the latest progress in anticancer mechanisms and combined therapies for oncolytic viruses.

关 键 词：疱疹病毒4型 人 胃肿瘤 肿瘤病毒感染 相关性 肿瘤形成过程 溶瘤病毒 

分 类 号：R735.2[医药卫生—肿瘤]