深部脑刺激治疗耐药癫痫研究进展  

Deep brain stimulation for drug-resistant epilepsy

作　　者：石燕婷 杜倩雯 臧轲君 吴怀宽 苏永鑫 刘学伍[1] Shi Yanting;Du Qianwen;Zang Kejun;Wu Huaikuan;Su Yongxin;Liu Xuewu(Department of Neurology, Qilu Hospital, Shandong University, Jinan 250012, China;Electroencephalogram Room, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, China)

机构地区：[1]山东大学齐鲁医院神经内科,济南250012 [2]山东省千佛山医院脑电图室,济南250014

出　　处：《中华神经科杂志》2019年第4期339-343,共5页Chinese Journal of Neurology

摘　　要：深部脑刺激(DBS)通常被用于治疗运动障碍性疾病如帕金森病,现有的证据表明DBS对难治性癫痫也可能有作用,并受多种因素的影响。研究者发现刺激丘脑前核和海马体可以降低难治性癫痫的发作频率,而刺激其他部位的作用尚不明确。影像学是否显示有大脑结构异常以及电极位置是否准确,会影响个体效果。而且某些癫痫发作类型可能对特定部位刺激反应更好。尽管已经确定了数个与DBS治疗效果相关的因素,但仍有很大的未知空间需要进行深入探究。Deep brain disease stimulation (DBS) is commonly used to treat movement disorders such as Parkinson disease, and current evidence suggests that DBS may also be useful for refractory epilepsy and is affected by a variety of factors. Studies show that stimulation of the anterior nucleus of the thalamus and hippocampus may decrease the frequency of refractory seizures. The efficacy of stimulating other targets remains inconclusive. An absence of structural abnormality on imaging and electrode position are associated with stimulation efficacy. Certain seizure types may respond more favorably to specific targets. There are several factors that potentially predict seizure outcome following DBS, but more large-scale clinical trials are needed.

关 键 词：刺激 难治性癫痫 疗效 预测因子 安全性 

分 类 号：R742.1[医药卫生—神经病学与精神病学]