3D打印非共面模板与共面坐标模板辅助放射性粒子植入治疗盆壁复发妇科肿瘤的术前计划对比  

Comparison of preoperative planning of radioactive seed implantation for pelvic wall recurrent gynecological malignant tumors between 3D-printing non-coplanar template and 3D-printing coplanar template

作　　者：曲昂[1] 王俊杰[1] 姜玉良[1] 孙海涛[1] 江萍[1] 吉喆[1] 郭福新[1] 范京红[1] 李卫燕[1] Qu Ang;Wang Junjie;Jiang Yuliang;Sun Haitao;Jiang Ping;Ji Zhe;Guo Fuxin;Fan Jinghong;Li Weiyan(Department of Radiation Oncology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院肿瘤放疗科,北京100191

出　　处：《中华医学杂志》2019年第11期841-843,共3页National Medical Journal of China

摘　　要：目的比较放射性粒子植入治疗盆壁复发妇科恶性肿瘤采用3D-打印非共面模板(3D-PNCT)和3D-打印共面坐标模板(3D-PCT)术前计划参数的差异,指导临床应用。方法选取2016年1月至2018年3月北京大学第三医院应用放射性粒子植入治疗的盆壁复发妇科恶性肿瘤患者33例,共37个病灶。中位年龄50岁(32~71岁)。病灶体积为40.0(4.6~332.4)cm^3。所有患者均进行3D-PNCT和3D-PCT术前计划设计。同一患者的两种模板计划90%靶区体积的剂量(D90)保持近似。计划参数的比较采用Wilcoxon检验或Kruskal-Wallis检验。结果两组靶区D90相似(P>0.05)。3D-PNCT组每例患者通过肠管针数和破骨针数均少于3D-PCT组[0(0~13),0(0~25),Z=-2.941,P<0.05;0(0~3),0(0~25),Z=-2.232,P<0.05]。结论对于盆壁复发妇科恶性肿瘤患者,两种模板术前计划均可达到处方剂量,3D-PNCT引起的损伤小,应用更安全。Objective To compare the difference of preoperative planning parameters between 3D-printing non-coplanar template(3D-PNCT)and 3D-printing coplanar template(3D-PCT)in the treatment of pelvic wall recurrent gynecological malignant tumor with radioactive seeds implantation,and to guide the clinical application.MethodsFrom January 2016 to March 2018,33 patients with pelvic wall recurrent gynecological malignant tumor were treated with radioactive seeds implantation assisted by 3D-printing template and in Peking University Third Hospital.All patients underwent 3D-PNCT and 3D-PCT preoperative planning.The D90 of target remained similar for the same patient.The parameters were compared with Wilcoxon test or Kruskal-Wallis test.Results D90 was similar between the two groups(P>0.05).The number of inserting needles through intestine and bone in 3D-PNCT group was less than that in 3D-PCT group(0(0-13),0(0-25),Z=-2.941,P<0.05;0(0-3),0(0-25),Z=-2.232,P<0.05).ConclusionFor patients with gynecological malignancies with pelvic recurrence,both of the two peroperative plans could achieve prescription dose,but 3D-PNCT is more safer.

关 键 词：放射治疗剂量 碘放射性同位素 肿瘤复发 局部 生殖器肿瘤 女(雌)性 

分 类 号：R737.3[医药卫生—肿瘤] TP391.73[医药卫生—临床医学]