黄芫花中酚类成分  

Phenolic constituents from Wikstroemia chamaedaphne

作　　者：梁雪 焦莹莹 王雯晧 李石飞[1] 张立伟[1] LIANG Xue;JIAO Ying-ying;WANG Wen-hao;LI Shi-fei;ZHANG Li-wei(Key Laboratory of Chemical Biology and Molecular Engineering of Education Ministry,Institute,of Molecular Science,Shanxi University,Taiyuan 030006,China;Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China)

机构地区：[1]山西大学分子科学研究所化学生物学与分子工程教育部重点实验室,山西太原030006 [2]山西大学中医药现代研究中心,山西太原030006

出　　处：《中国中药杂志》2019年第5期962-967,共6页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(31800293);山西省面上青年基金项目(201601D021157)

摘　　要：采用硅胶、Sephadex LH-20、ODS和制备型HPLC等色谱分离技术对黄芫花中的酚类成分进行了分离纯化,并通过波谱学数据进行结构鉴定。从中共分离鉴定13个酚类化合物,其中有5个黄酮及苷类:luteolin 7-O-β-D-glucopyranoside(1),luteolin 4'-O-β-D-glucopyranoside(2),kaempferol 3-O-β-D-glucopyranoside(3),chrysoeriol 4'-O-β-D-glucopyranoside(4),金圣草黄素(5); 8个木脂素及苷类:(-)-secoisolariciresinol(6),acanthosessilin A(7),(-)-nortrachelogenin(8),(+)-异落叶松树脂醇(9),芝麻素(10),丁香脂素(11),(+)-epipinoresinol(12),[3,3',4,4'-tetrahydro-6,6'-dimethoxy-3,3'-bi-2H-benzopyran]-4,4'-diol(13)。化合物1,3,5～8,10,11,13为首次从本植物中分离得到,化合物1,5,7,10,13为首次从荛花属植物中分离得到。The phenolic constituents of Wikstroemia chamaedaphne were investigated by various column chromatographic methods including silica gel,Sephadex LH-20,ODS and preparative HPLC,and their chemical structures were identified by physico-chemical properties and spectral analyses. Thirteen phenolic compounds were isolated and elucidated,including five flavonoids: luteolin 7-O-β-D-glucopyranoside(1),luteolin 4’-O-β-D-glucopyranoside(2),kaempferol 3-O-β-D-glucopyranoside(3),chrysoeriol 4’-O-β-D-glucopyranoside(4),chrysoeriol(5);and eight lignans:(-)-secoisolariciresinol(6),acanthosessilin A(7),(-)-nortrachelogenin(8),(+)-isolariciresinol(9),sesamin(10),syringaresinol(11),(+)-epipinoresinol(12),and [3,3’,4,4’-tetrahydro-6,6’-dimethoxy-3,3’-bi-2 H-benzopyran]-4,4’-diol(13). Compounds 1, 3, 5-8, 10, 11 and 13 were obtained from the plants of W. chamaedaphne for the first time,and compounds 1,5,7,10 and 13 were obtained from the Wikstroemia genus for the first time.

关 键 词：黄芫花 酚类化合物 黄酮 木脂素 

分 类 号：R284.1[医药卫生—中药学]