Comparing the effects of different drugs on postoperative cognitive dysfunction in elderly patients  

作　　者：Liu-Jia-Zi Shao Fu-Shan Xue Rui-Juan Guo Li Zheng 

机构地区：[1]Department of Anesthesiology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China

出　　处：《Chinese Medical Journal》2019年第8期1007-1008,共2页中华医学杂志（英文版）

摘　　要：To the Editor:In a randomized controlled preliminary trial comparing effects of propofol,dexmedetomidine,and midazolam on postoperative cognitive dysfunction(POCD)in elderly patients undergoing hip or knee arthroplasty with combined spinal-epidural anesthesia,Li et al[1]showed that intraoperative sedation with propofol compared to dexmedetomidine can significantly decrease risk of POCD.Given that POCD is associated with major adverse consequences,for example,an increased mortality rate,reduced quality of life,and delayed long-term recovery,[2]their findings have potential implications.However,we note that this finding is totally different from the results of a recent large randomized controlled study in elderly patients undergoing hip arthroplasty with the peripheral nerve block,in which patients sedated with dexmedetomidine have a lower risk of POCD than those sedated with propofol.

关 键 词：POSTOPERATIVE cognitive dysfunction(POCD) elderly patients spinal-epidural ANESTHESIA 

分 类 号：R[医药卫生]