术后三维适形放疗联合卡培他滨化疗治疗进展期胃癌的临床效果  

The clinical result of progressive gastric cancer after operation by three-dimensional conformal radiotherapy combined with Kapetabine chemotherapy

作　　者：李叶 潘贤英 贺文财 李华 马吉成 韩海林 LI Ye;PAN Xianying;HE Wencai;LI Hua;MA Jicheng;HAN Hailin(No.1 Department of Radiotherapy, the Fifth People′s Hospital in Qinghai Province, Qinghai Province, Xining 810007, China)

机构地区：[1]青海省第五人民医院放疗一科,青海西宁810007

出　　处：《中国医药导报》2019年第11期101-104,共4页China Medical Herald

摘　　要：目的探讨术后三维适形放疗联合卡培他滨化疗治疗进展期胃癌的临床效果。方法回顾性分析青海省第五人民医院2012年1月～2017年12月收治的150例进展期胃癌患者临床资料,依据治疗方式不同分为两组,化疗组(卡培他滨化疗)50例和放疗联合化疗组(三维适形放疗联合卡培他滨化疗)100例,两组患者均连续治疗2个周期。观察两组进展期胃癌患者治疗前后生存质量情况,观察两组患者临床疗效和不良反应发生率。结果两组患者治疗前生存质量评分比较,差异无统计学意义(P> 0.05),治疗后两组患者生存质量评分均高于治疗前,且放疗联合化疗组患者生存质量评分高于化疗组,放疗联合化疗组患者缓解率高于化疗组,放疗联合化疗组患者白细胞减少、血红蛋白减少、恶心呕吐发生率均高于化疗组,差异均有统计学意义(P <0.05),两组患者血小板减少、肢端麻木发生率比较,差异无统计学意义(P> 0.05)。结论进展期胃癌术后三维适形放疗联合卡培他滨化疗,可以提高患者生存质量和临床治疗缓解率,但是白细胞减少、血红蛋白减少、恶心呕吐发生率较高。Objective To investigate the clinical effect of postoperative three-dimensional conformal radiotherapy combined with capecitabine chemotherapy in the treatment of advanced gastric cancer. Method The 150 cases' clinical data of progressive gastric cancer in the Fifth People's Hospital Qinghai province from January 2012 to December 2017 were analyzed retrospectively, and they were divided into two groups, 50 patients in the chemotherapy group (capecitabine chemotherapy) and 100 cases in the radiotherapy combined chemotherapy group (three-dimensional conformal radiotherapy combined Kapetabine chemotherapy) were treated for 2 consecutive cycles. The quality of life of patients in the two groups before and after treatment was observed, and the clinical efficacy and incidence of adverse reactions were observed. Results The life quality scores of patients in the two groups before treatment had no significant differences (P > 0.05). Quality of life scores in the two groups after treatment were higher than before the treatment, chemotherapy and radiotherapy patients quality of life score in the radiotherapy combined chemotherapy group was higher than chemotherapy group, remission rate of patients in the radiotherapy combined chemotherapy group was higher than chemotherapy group, leukopenia, hemoglobin reduces, the incidence of nausea and vomiting of patients in chemotherapy group were higher than chemotherapy group, the difference had statistical significance (P < 0.05), There was no significant difference in the incidence of thrombocytopenia and extremity numbness between the two groups (P > 0.05). Conclusion The progressive gastric cancer after operation by three-dimensional conformal radiotherapy combined with kapetabine chemotherapy, which could increase life quality and the clinical treatment remission rate, but the incidence of leucopenia, reducing hemoglobin, and nausea vomiting rate are high.

关 键 词：进展期胃癌 三维适形放疗 卡培他滨 化疗 生存质量 缓解率 

分 类 号：R735.2[医药卫生—肿瘤]