PET/CT摄取指标与复发卵巢癌患者二次减瘤效果及预后的关系分析  

Correlation of PET/CT metrics with optimal debulking and prognosis in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery

作　　者：诸一鸣[1] 陈平[2] 朱滔[1] 张英丽[1] 郑爱文[1] ZHU Yiming;CHEN Ping;ZHU Tao(Department of Gynecological Oncology,Zhejiang Cancer Hospital,Hangzhou 310022,China)

机构地区：[1]浙江省肿瘤医院妇瘤科,杭州310022 [2]浙江省肿瘤医院麻醉科,杭州310022

出　　处：《浙江医学》2019年第8期768-771,共4页Zhejiang Medical Journal

基　　金：浙江省中医药科学研究基金计划(2017ZA031);浙江省医药卫生科技计划项目(2014KYA010)

摘　　要：目的探讨PET/CT相关摄取指标与复发性卵巢癌患者二次减瘤效果及无进展生存期(PFS)之间的关系。方法本研究纳入了2013年1月至2015年12月进行二次减瘤术的复发卵巢癌患者62例,均在术前90d内行PET/CT检查,记录PET/CT摄取指标包括最大标准摄取值(SUVmax)、代谢活跃的肿瘤体积(MTV)和病灶总糖酵解值(TLG),分析其与复发卵巢癌患者二次减瘤效果及预后的相关性。结果研究结果显示PET/CT摄取指标中MTV与TLG(P=0.012,P=0.003)与二次减瘤效果有相关性(MTV≤9.87ml及TLG≤40.83g的患者二次减瘤达到理想效果的比率高于MTV>9.87ml和TLG>40.83g的患者),但是SUVmax与肿瘤细胞减灭效果之间没有明显的相关性(P=0.267);MTV>9.87ml及TLG>40.83g的患者的PFS明显缩短(P=0.048,P=0.024),而SUVmax与患者预后之间无显著相关性(P=0.060)。结论反映肿瘤代谢负荷的PET/CT摄取指标与复发卵巢癌患者的二次减瘤效果及预后有相关性。Objective To investigate the relationship of PET/CT metrics with the effect of optimal debulking and prognosis in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery.Methods Clinical data of 62 patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery in zhejiang cancer hospital between January 2013 to December 2015 were retrospectively reviewed.All patients underwent PET/CT examination within 90 days before surgery,the uptake metrics included maximum standardized uptake values(SUVmax),metabolically active tumor volumes(MTV)and total lesion glycolysis(TLG).The correlation of different PET/CT uptake metrics with the effect of secondary debulking and progression-free survival(PFS)in patients with recurrent ovarian cancer was analyzed.Results Among the uptake metrics,MTV and TLG were correlated with the effect of secondary debulking,patients with MTV≤9.87ml and TLG≤40.83g had higher rates of ideal secondary debulking than those with MTV>9.87ml and TLG>40.83g(P=0.012,P=0.003);but there was no significant correlation between SUVmax and the effect of debulking(P=0.267).Patients with a TLG≥40.83g and MTV>9.87ml had significantly shorter PFS(P=0.048,P=0.024).SUVmax was not significantly related to PFS(P=0.060).Conclusion PET/CT uptake metrics MTV and TLG that reflect metabolic tumor burden are associated with the effect of secondary debulking and prognosis in patients with recurrent ovarian cancer.

关 键 词：复发卵巢癌 二次减瘤 PET/CT 预后 

分 类 号：R730.44[医药卫生—肿瘤] R737.31[医药卫生—临床医学]