抑癌基因甲基化与胃癌关系研究进展  

Research progress of relationships between tumor suppressor gene methylation and gastric cancer

作　　者：米志宽[1] 赵菊梅[1] MI Zhikuan;ZHAO Jumei(Yan’an University Medical College(Yan’an 716000))

机构地区：[1]延安大学医学院,延安716000

出　　处：《陕西医学杂志》2019年第5期679-680,F0003,共3页Shaanxi Medical Journal

基　　金：陕西省教育厅专项科研计划项目(17JK0867);延安大学创新创业项目(D2018191);延安大学继续教育专项(YDJZ2016-01)

摘　　要：肿瘤是遗传学和表遗传学共同作用的结果。胃癌表遗传学主要表现为DNA甲基化和组蛋白修饰。几种抑癌基因的甲基化导致其功能缺失,在胃癌的发生发展和转移中起着非常重要的作用,本文对此作了综述。Cancer is the results of the interaction of genetics and epigenetics.Gastric cancer epigenetics mainly includes DNA methylation and histone modification.Methylation of several tumor suppressor genes leads to the loss of function and plays a very important role in the development and metastasis of gastric cancer,which is reviewed in this paper.

关 键 词：胃癌 抑癌基因 甲基化 CDH1基因 CDKN2A基因 HMLH1基因 

分 类 号：R735[医药卫生—肿瘤]