老年乳腺癌患者术后心理社会因素对情绪及免疫功能的影响分析  

Analysis of postoperative psychosocial factors on emotion and immunity in elder patients with breast cancer

作　　者：熊智萍[1] 王佳 Xiong Zhiping;Wang Jia(Department of Breast Thyroid Pancreas Surgery,Huangshi Central Hospital,Huangshi 435000,China)

机构地区：[1]黄石市中心医院乳甲胰腺外科,435000

出　　处：《中华保健医学杂志》2019年第2期154-157,共4页Chinese Journal of Health Care and Medicine

摘　　要：目的探讨老年乳腺癌患者术后心理社会因素对情绪及免疫影响。方法选取2015年1月～2018年1月在黄石市中心医院进行乳腺癌手术的老年患者96例,使用简式简明心境问卷(POMS-SF)、领悟社会支持评定量表(PSSS)、应对问卷(DWI-CI)、埃森克人格问卷(EPQ),同时使用乳酸脱氢酶释放法检测血清自然杀伤(natural killer,NK)细胞活性,ELISA检测血清干扰素-γ(INF-γ)含量,MTT法检测淋巴细胞增殖能力,检测患者手术前后情绪和机体免疫功能受心理社会因素影响状况。结果手术后患者精力、紧张-焦虑、迷惑-混乱、抑郁-沮丧、疲乏-惰性、愤怒-敌意及POMS-SF总分较手术前显著升高,差异有统计学意义(P <0.05);血清INF-γ含量及NK细胞活性较手术前显著降低,差异有统计学意义(P <0.05)。家外支持高得分、家内支持高得分、主动行为高得分、主动认知高得分、回避低得分、精神质低得分、内-外向高得分、神经质低得分、掩饰高得分患者术前术后患者情绪得分均低于同指标内另一种得分患者,差异有统计学意义(P <0.05)。结论老年乳腺癌患者术后其情绪和免疫功能均低于术前,而社会支持高、神经质程度低、主动认知和主动行为多、外向、回避少者情绪状况和免疫功能相对较好。Objective To analyze the influence of postoperative psychosocial factors on emotion and immune in elderly patients with breast cancer. Methods A total of 96 elderly patients with breast cancer who underwent surgery in our hospital from January 2015 to January 2018 were enrolled in this study. The POMS-SF,PSSS,DWI-CI) and EPQ (EQQQ). Serum NK cell activity was measured by lactate dehydrogenase release assay. Serum INF-γ level was measured by ELISA. The proliferation of lymphocytes was detected by MTT assay. Before and after the detection of patients with emotional and immune function by psychosocial factors. Results The scores of postoperative stress,anxiety,confusion - disorder,depression - depression,fatigue - inertia,anger - hostility and POMS - SF score were significantly higher than those before surgery(P < 0.05). The serum INF-γ level and NK cell activity in postoperative patients were significantly lower than those before surgery(P < 0.05). The scores of home support high score,home support high score,active behavior score and active cognitive score,Avoidance low score,mental quality low score,internal-external high score,neuroticism score,occult high scores patients before and after the patients' emotional scores were lower than the other indicators with the same score in patients with a statistically significant difference(P < 0.05). Conclusion Elderly patients with breast cancer have lower emotion and immune function than those without preoperative surgery. High social support,low neuroticism,active cognition and active behavior,and less outward and less avoidance mood and immune function are relatively better.

关 键 词：心理社会因素 乳腺癌 手术 情绪 免疫功能 

分 类 号：R737.9[医药卫生—肿瘤]