神经节苷脂联合灯盏花素治疗HIE的应用研究  

Application of ganglioside combined with breviscapine in the treatment of HIE

作　　者：于波[1] YU Bo(Department of Neonatology,Jiamusi Central Hospital in Heilongjiang Province,Jiamusi 154002,China)

机构地区：[1]黑龙江省佳木斯市中心医院新生儿科,黑龙江佳木斯154002

出　　处：《中国现代医生》2019年第10期56-58,共3页China Modern Doctor

摘　　要：目的探讨神经节苷脂联合灯盏花素治疗新生儿缺氧缺血性脑病(hypoxic ischemic encephalopathy,HIE)的临床价值。方法选取我院儿科在收治的86例HIE患儿,采用随机数字表法进行分组,实验组与对照组各43例;对照组予以神经节苷脂治疗,实验组予以神经节苷脂联合灯盏花素注射液治疗,对比两组患儿的治疗效果、新生儿神经行为测定评分(neonatal behavioral neurological assessment,NBNA)以及血清肌酸磷酸激酶-BB(creatine kinaseBB,CK-BB)、心肌肌钙蛋白I(cardiac Troponin I,cTnI)水平变化及后遗症发生率。结果实验组的治疗总有效率高于对照组(P<0.05);实验组患儿的NBNA评分、血清CK-BB、cTnI水平的改善效果均优于对照组(P<0.05)。随访半年,实验组患儿的后遗症发生率显著低于对照组(P<0.05)。结论应用神经节苷脂联合灯盏花素注射液治疗新生儿缺氧缺血性脑病效果理想,对促进患儿神经功能恢复、改善血清CK-BB及cTnI水平具有重要帮助,还可有效减少相关后遗症。Objective To explore the clinical value of ganglioside combined with breviscapine in the treatment of neonatal hypoxic ischemic encephalopathy(HIE).Methods Eighty-six children with HIE admitted to our hospital were randomly divided into two groups,the experimental group and the control group,each with 43 cases.The control group was treated with ganglioside,and the experimental group was given ganglioside combined with breviscapine.The therapeutic effects of the two groups,neonatal behavioral neurological assessment(NBNA),serum creatine kinase-BB(CK-BB),cardiac troponin(cTnI),and incidence of sequelae were compared.Results The total effective rate of the experimental group was higher than that of the control group(P<0.05).The improvement of NBNA score,serum CK-BB and cTnI levels in the experimental group were better than those in the control group(P<0.05).After six months of follow-up,the incidence of sequelae in the experimental group was significantly lower than that in the control group(P<0.05).Conclusion The application of ganglioside combined with breviscapine injection in the treatment of neonatal hypoxic ischemic encephalopathy is effective,which is helpful for promoting the recovery of neurological function and improving serum CK-BB and cTnI levels,and can effectively reduce related sequelae.

关 键 词：神经节苷脂 灯盏花素注射液 新生儿缺氧缺血性脑病 神经功能 

分 类 号：R742[医药卫生—神经病学与精神病学]