高压氧治疗对阿尔茨海默病患者认知功能及血清Humanin水平的影响  

Effect of hyperbaric oxygen therapy on cognitive function and serum Humanin level in patients with Alzheimer′s disease

作　　者：徐玉振[1] 王茜[2] 单敏[1] 王涛[1] 杨位霞 张新萍[1] Xu Yuzhen;Wang Qian;Shan Min;Wang Tao;Yang Weixia;Zhang Xinping(Department of Neurology, Taian City Central Hospital, Taian 271000, China;Department of Central Laboratory, Taian City Central Hospital, Taian 271000, China;Department of Neurology, Zhongshan Hospital, Qingpu Branch, Shanghai 201700, China)

机构地区：[1]泰安市中心医院神经内科,271000 [2]泰安市中心医院中心实验室,271000 [3]复旦大学附属中山医院青浦分院神经内科,上海201700

出　　处：《中华诊断学电子杂志》2019年第2期83-86,共4页Chinese Journal of Diagnostics(Electronic Edition)

基　　金：山东省保健科技协会课题(SDBJKT20180030);泰安市科技发展计划(2017NS0155)

摘　　要：目的探讨高压氧(HBO)治疗对阿尔茨海默病(AD)患者认知功能及血清Humanin水平的影响。方法选取2015年6月至2017年6月在泰安市中心医院神经内科住院的轻中度AD患者,共72例,采用随机数字表法随机分为对照组和HBO治疗组,每组各36例。对照组给予常规治疗,HBO治疗组在对照组的基础上给予HBO治疗,两组疗程均为2个月。比较两组患者治疗前后简易精神量表(MMSE)评分、蒙特利尔认知量表(MoCA)评分及血清Humanin水平变化情况。结果治疗前,对照组MMSE评分、MoCA评分及血清Humanin水平分别为(15.35±2.12)分,(17.08±2.73)分,(147.2±39.6)ng/L;HBO治疗组MMSE评分、MoCA评分及血清Humanin水平分别为(15.29±2.43)分,(17.16±2.61)分,(141.8±41.3)ng/L,两组比较均差异无统计学意义(t=0.11,-0.13, 0.57;均P>0.05);治疗2个月后,对照组MMSE评分、MoCA评分及血清Humanin水平分别为(18.57±3.59)分,(20.46±3.07)分,(180.9±48.1)ng/L,低于HBO治疗组[(20.68±2.97)分,(22.74±3.28)分,(216.5±52.9)ng/L],差异具有统计学意义(t=-2.72,-3.05,-2.99;均P<0.01);血清Humanin水平与MMSE评分、MoCA评分均呈正相关(r=0.628,0.691;均P<0.05)。结论 HBO可改善AD患者的认知功能,其作用机制可能与升高血清Humanin的水平有关。Objective To investigate the effect of hyperbaric oxygen (HBO) on cognitive function and serum Humanin expression in patients with Alzheimer′s disease (AD). Methods From June 2015 to June 2017, 72 patients with mild to moderate AD admitted to the Neurology of Taian Central Hospital were selected. The patients were divided into control group and HBO treatment group by random number table method, each group with 36 patients. The control group was given conventional treatments and HBO treatment group was treated with HBO based on the conventional treatments, both groups were treated for 2 months. Mini-mental state examination (MMSE) scores, Montreal Cognitive Assessment (MoCA)scores and serum levels of Humanin in the two groups were compared before and after treatment. Results Before treatment, the MMSE score, MoCA score and serum Humanin level of the control group were (15.35±2.12) points,(17.08±2.73) points,(147.2±39.6) ng/L, respectively. The MMSE score, MoCA score and serum Humanin level in the HBO treatment group were (15.29±2.43) points,(17.16±2.61) points,(141.8±41.3) ng/L, respectively, there were no significant differences between the two groups ( t =0.11,-0.13 , 0.57, all P >0.05). After treatment, the MMSE score, MoCA score and serum Humanin level of the control group were (18.57±3.59)points,(20.46±3.07)points,(180.9±48.1)ng/L, which were lower than those in the HBO treatment group [(20.68±2.97)points,(22.74±3.28)points,(216.5±52.9)ng/L, respectively], the differences were significant ( t =-2.72,-3.05,-2.99,all P <0.01). Serum Humanin level was positively correlated with MMSE score ( r =0.628, P <0.05), and MoCA score ( r =0.691, P <0.05). Conclusion Hyperbaric oxygen can improve the cognitive function of AD patients, and the mechanism may be related to the increased serum levels of Humanin.

关 键 词：阿尔茨海默病 高压氧 认知 HUMANIN 

分 类 号：R749.16[医药卫生—神经病学与精神病学]