细胞外囊泡在肝纤维化诊治中的研究进展  

Role of extracellular vesicles in diagnosis and treatment of liver fibrosis

作　　者：赵佳伟 王玉刚[2] 施敏[2] Jia-Wei Zhao;Yu-Gang Wang;Min Shi(School of Medicine,Jiangsu University,Zhenjiang 212000,Jiangsu Province,China;Department of Gastroenterology,Shanghai Tongren Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 213300,China)

机构地区：[1]江苏大学医学院,江苏省镇江市212000 [2]上海交通大学医学院附属同仁医院消化内科,上海市213300

出　　处：《世界华人消化杂志》2019年第8期515-520,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金面上项目;Nos.81472242;81570549~~

摘　　要：细胞外囊泡(extracellular vesicles, EVs)介导细胞间的物质信号交流参与肝纤维化的发生发展,肝星状细胞(hepatic stellate cells, HSCs)和肝实质细胞分泌的EVs携带microRNA能激活邻近的HSCs,上调TGF-β信号通路,导致结缔组织生长因子表达增加,最终导致α-平滑肌肌动蛋白和胶原蛋白分泌增加,从而介导肝纤维化.另一方面,健康群体和间充质干细胞分泌的EVs对于肝纤维化起到一定的治疗作用.本文就EVs的结构、来源、功能及介导肝纤维化的发生发展与诊治的机制作一综述.Extracellular vesicles(EVs)mediate the intercellular communication of substances and are involved in the development of liver fibrosis.The vesicles secreted by hepatic stellate cells(HSCs)and hepatic parenchymal cells carry microRNAs to activate adjacent HSCs and up-regulate TGF-βsignaling pathway.This results in increased expression of connective tissue growth factor,which eventually leads to the expression ofα-smooth muscle actin and collagen,thereby mediating liver fibrosis.On the other hand,EVs secreted by healthy population and mesenchymal stem cells play a therapeutic role in liver fibrosis.This article reviews the structure,origin,and function of EVs as well as their role in the occurrence,development,diagnosis,and treatment of liver fibrosis.

关 键 词：细胞外囊泡 肝纤维化 MICRORNA 肝星状细胞 

分 类 号：R575.2[医药卫生—消化系统]