急性脑梗死患者外周血T细胞变化与神经损害、炎症及应激反应的相关性  

The correlation of peripheral blood T cell changes with nerve damage, inflammatory response and stress response in patients with acute cerebral infarction

作　　者：雷琦 朱婷鸽 刘蕊[3] LEI Qi;ZHU Ting-ge;LIU Rui(School of Internal Medicine,Shaanxi Normal University,Xi'an 710109,China;Department of Neurology,Second Affiliated Hospital of Air Force Military Medical University,Xi'an 710038,China;Department of Neurology,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710065,China)

机构地区：[1]陕西师范大学学府医院内科,陕西西安710109 [2]空军军医大学第二附属医院神经内科,陕西西安710038 [3]西安交通大学第一附属医院神经内科,陕西西安710065

出　　处：《海南医学院学报》2019年第9期654-657,共4页Journal of Hainan Medical University

基　　金：陕西省软科学研究计划项目(2016KRM127)~~

摘　　要：目的:探讨急性脑梗死患者外周血T细胞变化与神经损害、炎症及应激反应的相关性。方法:选取在本院接受急诊治疗的急性脑梗死患者108例作为脑梗死组,同期进行体检的健康老年志愿者100例作为正常对照组。对比两组外周血中CD4^+CD25^+调节性T淋巴细胞表达量以及血清中神经损害指标、炎症因子、氧化应激指标含量的差异。采用Pearson检验评估急性脑梗死患者外周血CD4^+CD25^+调节性T淋巴细胞表达量与梗死病情的内在联系。结果:脑梗死组外周血中CD4^+CD25^+调节性T淋巴细胞的表达量高于正常对照组;血清中神经损害指标UCH-L1、GFAP、Ang-1的含量高于正常对照组,IGF-1、BDNF的含量低于正常对照组;血清中炎症因子IL-1β、VCAM-1、IL-13、IL-18的含量均高于正常对照组;血清中氧化应激指标CAT、T-SOD的含量低于正常对照组,MDA的含量高于正常对照组。相关性分析证实,急性脑梗死患者外周血CD4^+CD25^+调节性T淋巴细胞表达量与机体神经损害指标、炎症因子、氧化应激指标的含量直接相关。结论:急性脑梗死患者外周血中CD4^+CD25^+调节性T淋巴细胞表达量异常增高,与患者神经损害及全身炎症应激反应加剧相关。Objective:To investigate the correlation of peripheral blood T cell changes with nerve damage,inflammatory response and stress response in patients with acute cerebral infarction.Methods:108patients with acute cerebral infarction who received emergency treatment in our hospital between September 2015 and August 2017 were selected as the cerebral infarction group,and 100 healthy elderly volunteers who underwent physical examination during the same period were selected as the normal control group.The differences in the expressions of CD4+CD25+regulatory T lymphocytes in peripheral blood as well as the levels of nerve damage indicators,inflammatory factors and oxidative stress indicators in serum were compared between the two groups.Pearson test was used to evaluate the intrinsic relationship between peripheral blood CD4^+CD25^+ regulatory T lymphocyte expression and infarction condition in patients with acute cerebral infarction.Results:Peripheral blood CD4^+CD25^+ regulatory T lymphocyte expression of the cerebral infarction group was higher than that of the normal control group;serum nerve damage indicators UCH-L1,GFAP and Ang-1levels were higher than those of the normal control group whereas IGF-1 and BDNF levels were lower than those of the normal control group;serum inflammatory factors IL-1β,VCAM-1,IL-13and IL-18levels were higher than those of the normal control group;serum oxidative stress indicators CAT and T-SOD levels were lower than those of the normal control group whereas MDA level was higher than that of the normal control group.Correlation analysis confirmed that peripheral blood CD4^+CD25^+ regulatory T lymphocyte expression in patients with acute cerebral infarction was directly correlated with the levels of nerve damage indicators,inflammatory factors and oxidative stress indicators. Conclusion:The abnormal increase of peripheral blood CD4^+CD25^+regulatory T lymphocyte expression in patients with acute cerebral infarction is related to the aggravation of nerve damage and systemic inflammatory s

关 键 词：急性脑梗死 T细胞 神经损害 炎症反应 氧化应激反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]