抗苗勒管激素在卵巢恶性肿瘤诊治中的应用  

Application of anti-mullerian hormone in diagnosis and treatment of ovarian malignant tumor

作　　者：倪晶晶 周晓美[1] 苏亦平[1] NI Jing-jing;ZHOU Xiao-mei;SU Yi-ping(Department of Gynecology,Obstetrics and Gynecology Hospital,the Affiliated Hospital of Nanjing MedicalUniversity,Nanjing 210004,Jiangsu,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)妇科

出　　处：《东南国防医药》2019年第3期277-281,共5页Military Medical Journal of Southeast China

基　　金：国家自然科学基金(81871138)

摘　　要：抗苗勒管激素(AMH)是由睾丸支持细胞和卵泡颗粒细胞合成的糖蛋白二聚体,通过与靶细胞膜上的特异性受体结合而发挥作用,是性腺发育及男性性别分化的重要调节因子,对卵泡成熟的调控也有重要作用,故其在生殖内分泌领域一直备受关注。近年来,越来越多研究发现AMH与某些妇科恶性肿瘤相关,在卵巢颗粒细胞瘤的诊断、治疗、随访及监测中的作用日益突显,且对AMH受体阳性卵巢上皮性癌细胞的生长、侵袭、转移及耐药有抑制作用,有望成为特定妇科恶性肿瘤治疗的新药物,并且对于年轻癌症者生育功能的保护,也有一定益处。文章主要对AMH在卵巢颗粒细胞瘤的诊治、卵巢上皮性癌的治疗及年轻癌症患者卵巢功能保护的临床应用进行综述。Anti-mullerian hormone(AMH)is a glycoprotein hormone produced by Sertoli cells of the testis and granulosa cells of the ovary.To play its biological function,AMH binds to its specific receptors on target cell membranes.AMH is a vital regulator of gonadal development and male sex differentiation ,it also plays an important role in regulating follicular maturation.Therefore, AMH has been receiving much attention in the field of Reproductive medicine and Endocrinology.Recently,more and more studies have revealed that AMH has a certain relationship with some gynecological malignancy.Its role in the diagnosis,treatment,follow-up and monitoring of granulosa cell tumor becomes increasingly prominent.Furthermore,it exhibits an inhibitory effect on the proliferation,invasion,metastasis and drug resistance of AMHR-positive tumors,showing its potential to be a novel anticancer agent for gynecologic tumors.It is also beneficial for the protection of fertility in those young women suffering from cancers.This article reviews the clinical application of AMH in ovarian granulosa cell tumor,ovarian epithelial cancer and ovarian function protection.

关 键 词：抗苗勒管激素 卵巢颗粒细胞瘤 卵巢上皮性癌 卵巢功能保护 

分 类 号：R737.31[医药卫生—肿瘤]