术前营养预后指数和体质量指数与结直肠癌病人预后关系的研究  

Study on the correlations of the PNI and BMI with prognosis in patients with colorectal cancer

作　　者：朱伟伟 范文华[1] 方可[1] 黄鹤[2] ZHU Wei-wei;FAN Wen-hua;FANG Ke;HUANG He(Department of Gastrointestinal Surgery,The Second People's Hospital of Wuhu,Wuhu Anhui 241000;Department of Gastrointestinal Surgery,Yijishan Hospital of Wannan Medical College,Wuhu Anhui 241000,China)

机构地区：[1]安徽省芜湖市第二人民医院胃肠外科,241000 [2]皖南医学院弋矶山医院胃肠外科,安徽芜湖241000

出　　处：《蚌埠医学院学报》2019年第4期442-445,共4页Journal of Bengbu Medical College

基　　金：安徽省高等学校自然科学研究重点项目(KJ2016A717)

摘　　要：目的:探讨术前营养预后指数(PNI)和体质量指数(BMI)与结直肠癌病人术后预后的关系。方法:选取接受结直肠癌根治术的病人116例,使用受试者工作特征曲线曲线得出PNI的截断值。使用Kaplan-Meier法绘制术后生存曲线,Cox回归模型分析影响术后生存的独立影响因素。结果:PNI的截断值为47.5,高PNI组5年生存率36.2%高于低PNI组的18.8%(P<0.05);单因素分析表明肿瘤分化程度、浸润深度、淋巴结转移、远处转移、临床分期、PNI、BMI与病人预后相关(P<0.05～P<0.01)。Cox多因素分析结果表明分化程度、远处转移、临床分期、PNI和BMI是结直肠癌根治术后病人预后的独立影响因素(P<0.05)。PNI与BMI联合预测病人预后价值高于其单独预测价值。结论:PNI与BMI是结直肠癌病人术后预后的独立影响因素,使用PNI与BMI联合评估病人预后能够提高准确性。Objective:To explore the correlations of the prognostic nutritional index(PNI) and body mass index(BMI) with prognosis in patients with colorectal cancer. Methods:The clinicopathological data of 116 colorectal cancer patients treated with radical colectomy were retrospectively analyzed. The receiver operating characteristic curve was used to determine the cut-off value of PNI,the survival curve was plotted using the Kaplan-Meier method,and the cox regression model was used to analyze the independent factor affecting postoperative. Results:The cut-off value of PNI was 47. 5. The 5-year survival rate in high P survival NI group(36. 2%) was higher than that in low PNI group(18. 8%)(P < 0. 05). The results of univariate analysis showed that the tumor differentiation,invasion depth,lymph node metastasis,distant metastasis,clinical staging,PNI and BMI were correlation with prognosis of patients(P <0. 05 to P <0. 01). The results of Cox multi-factor analysis showed that the tumor differentiation,distant metastasis,clinical staging,PNI and BMI were the independent factor affecting prognosis of patients(P < 0. 05). The value of PNI combined with BMI in predicting the prognosis of patients was higher than that of PNI or BMI(P <0. 05). Conclusions:PNI and BMI are the independent factors affecting prognosis of patients with colorectal cancer,and the combination of PNI with BMI can improve the accuracy in evaluating prognosis of patients.

关 键 词：结直肠肿瘤 营养预后指数 体质量指数 

分 类 号：R735.7[医药卫生—肿瘤]