β淀粉样蛋白1-40、血脂及炎症因子在阿尔茨海默病中的临床意义  

Clinical significance of β-amyloid 1-40, blood lipids and inflammatory factors in Alzheimer disease

作　　者：隗永健 郇玲 陈大龙[1] 李鹏 WEI Yongjian;XUN Ling;CHEN Dalong;LI Peng(Jiamusi Central Hospital,Jiamusi 154000 Heilongjiang,China)

机构地区：[1]佳木斯市中心医院,黑龙江佳木斯154000

出　　处：《中国民康医学》2019年第6期1-3,共3页Medical Journal of Chinese People’s Health

基　　金：黑龙江省卫生计生委科研课题(编号:2018145)

摘　　要：目的:分析阿尔茨海默病血浆中β淀粉样蛋白1-40(Aβ1-40)、血脂指标及相关炎症因子的临床意义。方法:择取收治的85例阿尔茨海默病患者作为研究对象,按照阿尔茨海默病评定量表-认知量表(ADAS-Cog)分为两组,轻度组(ADAS-Cog总分<20分)48例;中重度组(ADAS-Cog总分≥20分)37例。同时随机选取同期40例健康体检者作为对照组,空腹抽取静脉血,全自动生化仪检测受试者血浆中总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL);酶联免疫吸附试验检测血浆中IL-6、Aβ1-40、M-CSF、IL-1β、TNF-α水平,并进行比较。结果:AD两组患者的血脂水平明显高于对照组,差异有统计学意义(P<0.05),但AD两组间血脂水平比较,差异无统计学意义(P>0.05)。AD两组血浆中Aβ1-40、IL-6、M-CSF、IL-1β、TNF-α水平均高于对照组,除M-CSF外,差异均有统计学意义;中重度组除M-CSF明显低于轻度组外,IL-6、IL-1β、TNF-α均明显高于轻度组,差异均有统计学意义(P<0.05),AD两组间Aβ1-40差异无统计学意义(P>0.05)。结论:阿尔茨海默病患者的Aβ1-40、血脂水平及相关炎症因子水平均有所升高,其中相关炎症因子与疾病的发生发展呈正相关,这些指标或对临床诊断有一定意义。Objective: To analyze clinical significance of plasma β-amyloid 1-40 (Aβ1-40), blood lipid sand related inflammatory factors in Alzheimer disease (AD). Methods: 85 patients with AD were selected as the subjects and divided into mild group (ADAS-Cog total score <20 points, n=48) and severe group (ADAS-Cog total score ≥ 20 points, n=37) according to the ADAS-Cog scale. At the same time, 40 healthy subjects were randomly selected as the control group. The fasting venous blood was taken. The plasma total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL) were detected by using the automatic biochemical analyzer. The levels of plasma IL-6, Aβ1-40, M-CSF, IL-1β and TNF-α were detected by the enzyme-linked immunosorbent assay. The results of the two groups were compared. Results: The blood lipid levels of the two AD groups were significantly higher than those of the control group, and the differences were statistically significant (P<0.05);however, there was no significant difference between the two AD groups (P>0.05). The levels of Aβ1-40, IL-6, M-CSF, IL-1β and TNF-α in the mild group were significantly higher than those in the control group. Except Aβ1-40 and M-CSF, the levels of other factors of the severe group were significantly higher than those of the control group, and the differences were statistically significant (P<0.05). Conclusions: The AD patients have elevated levels of Aβ1-40, blood lipid and related inflammatory factors. Among these, the related inflammatory factors are positively correlated with the occurrence and development of the disease, and may have certain significance for clinical diagnosis.

关 键 词：阿尔茨海默病 血脂 IL-6 AΒ1-40 M-CSF IL-1Β TNF-α 

分 类 号：R749.16[医药卫生—神经病学与精神病学]