自噬在肝细胞癌发生发展和免疫治疗调控中的作用及其机制  

Role and mechanism of autophagy in development and progression of hepatocellular carcinoma and regulation of immunotherapy

作　　者：王沐淇 李亚萍[1] 刘拉羊[1] 党双锁[1] 石娟娟[1] 贾晓黎[1] WANG Muqi;LI Yaping;LIU Layang(Department of Infectious Diseases,The Second Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710004,China)

机构地区：[1]西安交通大学第二附属医院感染科,西安710004

出　　处：《临床肝胆病杂志》2019年第5期1129-1134,共6页Journal of Clinical Hepatology

基　　金：国家自然科学基金青年项目(31500650);陕西省科学技术研究发展计划(2008K14-02)

摘　　要：自噬作为基础的生理现象,是维持细胞稳态和生理代谢的重要机制,还可以诱导细胞程序性死亡。目前大量研究证明,自噬在多种肿瘤的发生发展和演化过程中发挥重要作用,这为肿瘤的研究及治疗提供了新的思路。肝癌的发生机制极其复杂,其中免疫调控对肝癌发生、转移和侵袭的作用已经得到公认,近年来自噬被发现通过参与肿瘤免疫、氧化应激和维持细胞稳态等多方面影响肝癌进展,且可通过多种途径对肝癌免疫治疗效果产生影响。综述了自噬在肝癌发生发展和免疫治疗调控中的作用及其机制,以期深入了解自噬在肝癌中的重大影响和潜在的治疗价值。As a basic physiological phenomenon,autophagy plays an important role in maintaining cellular homeostasis and physiological metabolism and can also induce programmed cell death. At present,many studies have shown that autophagy plays an important role in the development,progression,and metastasis of various tumors,which provide new viewpoints for tumor research and treatment. Hepatocellular carcinoma has an extremely complex pathogenesis,and the effect of immunoregulation on the development,metastasis,and invasion of hepatocellular carcinoma has been generally accepted. Recent studies have found that autophagy is involved in tumor immunity,oxidative stress,and maintenance of cellular homeostasis and thus affect the progression of hepatocellular carcinoma. It may also influence the effect of immunotherapy via multiple pathways. This article reviews the role and mechanism of autophagy in the development and progression of hepatocellular carcinoma and the regulation of immunotherapy,in order to understand the significant influence of autophagy on hepatocellular carcinoma and the potential therapeutic value of autophagy.

关 键 词：癌 肝细胞 自噬 免疫疗法 综述 

分 类 号：R735.7[医药卫生—肿瘤]