干扰素基因刺激蛋白在慢性肝病发生发展中的抑制作用  

Stimulator of interferon genes inhibits the development and progression of chronic liver diseases

作　　者：张雪 李曼[1] 张鑫[1] 孙学华[1] 朱晓骏[1] 高亚婷[1] 高月求[1] ZHANG Xue;LI Man;ZHANG Xin(Department of Hepatology & Institute of Clinical Immunology,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院肝病科临床免疫研究所,上海201203

出　　处：《临床肝胆病杂志》2019年第5期1148-1152,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81673938;81774256;81473477;81503545);国家"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项(2012ZX10005004-002);上海市科委科技支撑项目(16401970600);上海市科委生物引导项目(16401931300);上海申康市级医院新兴前沿技术联合攻关项(SHDC12016121);中医优势病种培育项目(zybz-2017004);上海市中医药新兴交叉学科资助计划

摘　　要：干扰素基因刺激蛋白(STING)是调节肝脏内环境的一种重要先天胞质环状二核苷酸传感器,主要通过天然免疫应答,特异性T淋巴细胞应答和自噬等激活干扰素调节因子(IRF) 3/IRF7,抑制慢性乙型肝炎、肝纤维化和肝细胞癌等慢性肝病的发生与发展。介绍了STING的分布、结构特点、生物学功能、信号通路及其在慢性肝病发生发展中的作用,旨在阐述STING在干预慢性肝病中的作用,从而在研究治疗中取得新思路。Stimulator of interferon genes (STING) is an important congenital cytoplasmic cyclic dinucleotide sensor that regulates the internal environment of the liver. It activates IRF3/IRF7 and inhibits the development and progression of chronic liver diseases such as chronic hepatitis B,liver fibrosis,and hepatocellular carcinoma through innate immune response,specific T cell response,and autophagy. This article introduces the distribution,structural characteristics,biological functions,and signaling pathways of STING and its role in the development and progression of chronic liver diseases,in order to elaborate on the role of STING in the intervention of chronic liver diseases and provide new ideas for treatment.

关 键 词：干扰素基因刺激蛋白 肝疾病 信号传导 免疫 天然 综述 

分 类 号：R575[医药卫生—消化系统]