非酒精性脂肪性胰腺病的研究现状  

Current status of the research on nonalcoholic fatty pancreatic disease

作　　者：袁贝贝 谭玉娥[1] 刘京京 刘欢[1] 刘佳 宋清莲 戴光荣[1] YUAN Beibei;TAN Yue;LIU Jingjing(Department of Gastroenterology,Yan′An University Affiliated Hospital,Yan′An,Shaanxi 716000,China)

机构地区：[1]延安大学附属医院消化内科,陕西延安716000

出　　处：《临床肝胆病杂志》2019年第5期1161-1164,共4页Journal of Clinical Hepatology

基　　金：陕西省社会发展科技攻关项目(2016SF-120)

摘　　要：非酒精性脂肪性胰腺病(NAFPD)被定义为在无显著饮酒情况下与肥胖相关的胰腺脂肪沉积,其发病机制尚不十分明确。NAFPD与非酒精性脂肪性肝病、2型糖尿病、胰腺炎、胰腺肿瘤、胰十二指肠术后胰瘘等密切相关,其能够增强胰腺癌细胞扩散,促使胰腺癌患者早期死亡。NAFPD主要依赖于胰腺活组织病理学检查和影像学检查来评估与诊断,但临床实际中存在检测技术与诊断水平的局限性。NAFPD的主要防治手段包括减轻体质量、减肥手术及药物治疗。由于既往NAFPD相关文献报道较少,且在临床中未予以足够重视,导致其临床诊疗与处理存在明显差异,鉴于此,阐述了NAFPD的研究现状与诊疗进展。Nonalcoholic fatty pancreatic disease (NAFPD) is defined as pancreatic fat deposition associated with obesity in the absence of significant drinking,and its pathogenesis remains unclear. NAFPD is closely associated with nonalcoholic fatty liver disease (NAFLD),type 2 diabetes,pancreatitis,pancreatic tumor,and pancreatic fistula after pancreaticoduodenal surgery and can promote the spread of pancreatic cancer cells and result in the early death of patients with pancreatic cancer. The diagnosis and evaluation of NAFPD mainly rely on pathological biopsy and imaging examination,but their clinical application is limited by detection techniques and diagnostic level. Major prevention and treatment methods for NAFPD include a reduction in body weight,bariatric surgery,and pharmacotherapy. Since there are few articles on NAFPD and it is not taken seriously in clinical practice,there are significant differences in the clinical diagnosis and treatment of this disease. Therefore,this article elaborates on the current status of research on NAFPD and the advances in its diagnosis and treatment.

关 键 词：非酒精性脂肪性胰腺病 流行病学 疾病特征 诊断 治疗 综述 

分 类 号：R576[医药卫生—消化系统]