长链非编码RNA调控肝癌上皮间质转化的研究进展  

Research Progress of Long Non-coding RNAs during Epithelial-Mesenchymal Transition of Liver Cancer

作　　者：周楚琦 许文倩 方路 姜孝新[1] ZHOU Chuqi;XU Wenqian;FANG Lu;JIANG Xiaoxin(The First Affiliated Hospital,University of South China,Hengyang,Hunan,421001,China)

机构地区：[1]南华大学附属第一医院,湖南衡阳421001

出　　处：《肿瘤药学》2019年第2期193-197,共5页Anti-Tumor Pharmacy

基　　金：湖南省重点研发计划项目(2018SK2095)

摘　　要：肝癌易发生侵袭转移,早期诊断率低,患者死亡率极高。上皮间质转化(EMT)是促进肿瘤细胞侵袭、转移的关键因素。长链非编码RNA(lncRNA)通过多种途径参与肝癌细胞EMT的调控,从而影响肝癌的发生和发展。本文主要对与EMT核心转录因子相关的lncRNA、促进肝癌EMT的lncRNA(lncRNA-ATB、LincRNA-ROR、lncRNA-ATB、lncTCF7等)及抑制肝癌EMT的lncRNA(lncRNA-CASC2、lincRNA-p21等)的研究进展进行综述。Liver cancer is prone to invasion and metastasis. It often gets low diagnosis rate in early stage but extremely high mortality. Epithelial-mesenchymal transition(EMT)is a key factor in promoting tumor cell invasion and metastasis. Long non-coding RNA(lnc RNA)participates in the regulation of EMT in hepatocarcinoma cells through various pathways,thus affecting the occurrence and development of liver cancer. This article focuses on lncRNAs that is related to EMT core transcription factors, and that promotes EMT of liver cancer such as lncRNAATB,Linc RNA-ROR,lnc RNA-ATB and lncTCF7,and that inhibits EMT of liver cancer such as lncRNA-CASC2 and lincRNA-p21.

关 键 词：长链非编码RNA 上皮间质转化 肝癌 

分 类 号：R735[医药卫生—肿瘤]