小型实验动物颞下颌关节骨关节炎动物模型的研究进展  

Research Progress in Animal Models of Temporomandibular Joint Osteoarthritis in Small Experimental Animals

作　　者：魏欣 杨禾丰[1] 胡瑜[1] 杨春[1] WEI Xin;YANG Hefeng;HU Yu;YANG Chun(Department of Prosthodontics,the Affiliated Stomatology Hospital of Kunming Medical University,Kunming 650500,China)

机构地区：[1]昆明医科大学附属口腔医院口腔修复科,昆明650500

出　　处：《医学综述》2019年第7期1375-1379,共5页Medical Recapitulate

基　　金：云南省科技厅-昆明医科大学应用基础研究联合专项资金项目(2018FE001〔-317〕)

摘　　要：颞下颌关节骨关节炎(TMJOA)是颞下颌关节紊乱病的重要类型之一。动物模型是研究疾病的重要手段,合适的动物模型有助于研究TMJOA的发病机制,探索有效的治疗措施。目前由于大型动物获得成本较高,特殊自发性TMJOA动物较少,小型动物中的鼠类及兔类常被用于制备TMJOA动物模型,目前常用的建模方法包括化学诱导(关节上腔注射碘醋酸钠、完全弗式佐剂、血管内皮生长因子、Ⅱ型胶原酶)、外科手术(关节盘部分切除、关节盘穿孔)、机械负荷刺激(被动大张口、改变咀嚼负荷)以及基因工程等。Temporomandibular joint osteoarthritis(TMJOA) is one of the most important types of temporomandibular joint disorders.Animal model is an important way of studying the diseases.Appropriate animal models are helpful to study the pathogenesis of TMJOA and explore the effective treatment measures.At present,because of the higher cost of obtaining large animals and scarcity of special spontaneous TMJOA animals,small animals such as rats and rabbits are often used in the preparation of TMJOA animal models.Currently the methods of modeling include chemical induction(suprarticular injection of sodium iodoacetate,complete Freund′s adjuvant,vascular endothelial growth factor,collagenaseⅡ),surgical operation(partial dissection of the articular disc, perforation of the articular disc),mechanical load stimulation(passive mouth opening, altered chewing load) and genetic engineering etc..

关 键 词：颞下颌关节 骨关节炎 动物模型 建模方法 基因工程 

分 类 号：R332[医药卫生—人体生理学]