阿托伐他汀钙联合氯吡格雷治疗短暂性脑缺血发作颅内动脉粥样硬化的效果及其对血清CysC水平的影响  

Effect of atorvastatin calcium combined with clopidogrel on transient ischemic attack and intracranial atherosclerosis and its influence on serum CysC level

作　　者：张召平 樊黎 ZHANG Zhao-ping;FAN Li(the Hospital of Fengxiang County,Baoji 721400,China)

机构地区：[1]凤翔县医院,陕西宝鸡721400

出　　处：《临床医学研究与实践》2019年第13期38-40,共3页Clinical Research and Practice

摘　　要：目的观察阿托伐他汀钙联合氯吡格雷治疗短暂性脑缺血发作(TIA)颅内动脉粥样硬化的效果及对血清CysC水平的影响。方法选择2016年8月至2018年8月本院收治的100例TIA颅内动脉粥样硬化患者为研究对象,以入院顺序奇偶性将其分为对照组(n=50,氯吡格雷治疗)和研究组(n=50,氯吡格雷联合阿托伐他汀钙治疗)。比较两组临床疗效、斑块面积、IMT、血清CysC水平、NIHSS评分及不良反应发生情况。结果研究组治疗总有效率为96.00%,显著高于对照组的76.00%(P<0.05)。治疗后,研究组斑块面积、IMT、血清CysC水平及NIHSS评分均显著优于对照组及治疗前(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论氯吡格雷联合阿托伐他汀钙治疗TIA颅内动脉粥样硬化的效果显著,可有效调节患者血清CysC水平,减轻其神经受损程度,且不良反应较少,安全性更高,值得大力推广。Objective To observe the effect of atorvastatin calcium combined with clopidogrel on transient ischemic attack (TIA) and intracranial atherosclerosis and its influence on serum CysC level.Methods A total of 100 cases with TIA and intracranial atherosclerosis admitted in our hospital from August 2016 to August 2018 were selected as the study objects and divided into control group (n=50,treated with clopidogrel) and study group (n=50,treated with clopidogrel combined with atorvastatin calcium ) according to the parity of admission sequence.The clinical efficacy,plaque area,IMT,serum CysC levels,NIHSS scores and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was 96.00%,which was significantly higher than 76.00% in the control group (P<0.05).After treatment,the plaque area, IMT,serum CysC level and NIHSS score in the study group were significantly better than those in the control group and before treatment(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Clopidogrel combined with atorvastatin calcium in the treatment of TIA patients with intracranial atherosclerosis has a significant effect,which can effectively regulate the level of serum CysC and reduce the degree of nerve damage in patients and have fewer adverse reactions and higher safety.It is worth promoting vigorously.

关 键 词：阿托伐他汀钙 氯吡格雷 短暂性脑缺血发作 颅内动脉粥样硬化 

分 类 号：R743.31[医药卫生—神经病学与精神病学]