表观遗传学与肺癌  

Epigenetics and Lung Cancer

作　　者：刘亚茹[1] 汪涛[1] 马羚[1] 王申森 黄华 黄映辉[1] LIU Ya-ru;WANG Tao;MA Ling;WANG Shen-sen;HUANG Hua;HUANG Ying-hui(School of Life Science and Biomedical,Beijing University of Technology,Beijing,100124,China)

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《现代生物医学进展》2019年第6期1176-1179,共4页Progress in Modern Biomedicine

基　　金：北京市科委重点项目(K2015311201501)

摘　　要：表观遗传是在指不影响遗传序列的情况下影响型状表达的方法。除了经典遗传方面,如点突变、颠换、插入与肺癌的发生有关,近年来研究显示表观遗传学对肺癌的发生也起到了重要的作用。本文主要从表观遗传学角度,简述了DNA甲基化、组蛋白修饰、非编码RNA尤其是mi RNA与肺癌的关系,甲基化主要是通过抑制原癌基因,促进抑癌基因表达导致肺癌,组蛋白修饰会促进抑癌基因的表达,非编码RNA可以作为肺癌诊断的生物标记物,为肺癌的早期诊断提供依据。Epigenetics refers to affecting the expression of a pattern without affecting the genetic sequence.In addition to the classical genetic,such as point mutations,transversion,insertion,in recent years found that epigenetics also played an important role in lung cancer.There is a brief description between the DNA methylation,histone modification,non-coding RNA,especially miRNA and lung cancer,methylation leading to lung cancer mainly through the inhibition of oncogene,promote tumor suppressor gene expression,histone modification can promote the expression of tumor suppressor gene,non-coding RNA can be used as a biomarker for the diagnosis of lung cancer,providing a basis for the early diagnosis of lung cancer.

关 键 词：DNA甲基化 组蛋白修饰 肺癌 MIRNA 

分 类 号：Q75[生物学—分子生物学] R734.2[医药卫生—肿瘤]