氧化应激与口腔扁平苔藓的研究进展  

Research Progress of Oxidative Stress and Oral Lichen Planus

作　　者：李新[1] 王赛男 孙银银 卢恕来[3] LI Xin;WANG Sai-nan;SUN Yin-yin;LU Shu-lai(Qingdao University, Shandong 266011, China)

机构地区：[1]青岛大学口腔医学院,硕士生山东266011 [2]大连医科大学,硕士生山东266011 [3]青岛市市立医院口腔医学中心

出　　处：《中华老年口腔医学杂志》2019年第2期118-122,共5页Chinese Journal of Geriatric Dentistry

基　　金：山东省医药卫生科技发展计划项目面上项目(项目编号:2015WS0327);山东省卫计委中医药科技发展计划项目(项目编号:2015-378);青岛市科技计划项目(项目编号:17-3-3-39-nsh)

摘　　要：口腔扁平苔藓(OLP)是一种常见的口腔黏膜慢性炎性疾病,其发病机制尚不明确,最近研究表明OLP患者体内存在氧化应激(OS),伴随脂质过氧化的增加,抗氧化防御系统失衡,活性氧族(R OS)及其引起的氧化损伤与OLP的发生发展密切相关。通过OLP中氧化应激的研究,可进一步阐明OLP的发病机制,并为OLP的治疗提供新的方向。文中就氧化应激与口腔扁平苔藓的研究进展作一综述。Oral lichen planus (OLP) is a common chronic inflammatory disease of oral mucosa, and its pathogenesis is still unclear. Recent studies have shown that oxidative stress (OS), is associated with the increase of lipid peroxidation and the imbalance of antioxidant defense system in patients with OLP. The oxidative damage caused by active oxygen (ROS) is closely related to the occurrence and development of OLP. Researches on oxidative stress are providing novel therapeutic targets of OLP. This paper reviews the research progress of oxidative stress and oral lichen planus.

关 键 词：氧化应激 口腔扁平苔藓 活性氧族 

分 类 号：R781.5[医药卫生—口腔医学]