头孢曲松预处理对局灶性脑缺血损伤的作用研究  

Effect of Ceftriaxone Preconditioning on Focal Cerebral Ischemia Injury

作　　者：庞乃清 PANG Naiqing(Cancer Hospital of Datong Second People’s Hospital,Shanxi Province 037006)

机构地区：[1]山西省大同市第二人民医院肿瘤医院,037006

出　　处：《医学理论与实践》2019年第9期1289-1291,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨头孢曲松预处理对局灶性脑缺血损伤的作用。方法:选取36只成年健康雄性SD大鼠,随机分为A组(模型组)、B组(假手术组)。A组建立大脑中动脉阻塞模型(MCAO),并随机分为A1组(参照)、A2组(头孢曲松预处理)。比较各组间神经功能缺陷评分变化及白细胞介质1β(IL-1β)表达。结果:A1组、A2组神经功能缺陷评分低于B组,差异有统计学意义(P<0.01),但A2组高于A1组,差异有统计学意义(P<0.01);A1组、A2组缺血半暗带皮层IL-1β水平均高于B组,差异有统计学意义(P<0.01),但A2组低于A1组,差异有统计学意义(P<0.01)。A1组、A2组纹状体IL-1β水平均高于B组,差异有统计学意义(P<0.01)。结论:头孢曲松预处理可逆转局灶性缺血损伤大鼠神经功能缺陷,考虑作用机制为抑制炎症反应,减轻脑组织损伤,需引起高度关注。Objective:To investigate the effect of ceftriaxone preconditioning on focal cerebral ischemia injury.Methods:Thirty-six adult healthy male SD rats were randomly divided into group A(model group) and group B(sham operation group).The middle cerebral artery occlusion model(MCAO) was established in group A and randomly divided into group A1(reference) and group A2(ceftriaxone pretreatment). The changes of neurological deficit score and the expression of interleukin-1 beta(IL-1β) were compared among the groups.Results:The scores of neurological deficits in group A1 and A2 were lower than those in group B, with statistical significance(P<0.01),but those in group A2 were higher than those in group A1(P<0.01);the levels of IL-1β in ischemic penumbra cortex in group A1 and A2 were higher than those in group B(P<0.01),but those in group A2 were lower than those in group A1(P< 0.01). The levels of IL-1β in striatum of group A1 and group A2 were higher than those of group B(P<0.01).Conclusion:Ceftriaxone preconditioning can reverse neurological deficits in rats with focal ischemic injury. Considering the mechanism of action, it is necessary to pay more attention to inhibiting inflammatory response and alleviating brain tissue damage.

关 键 词：局灶性脑缺血损伤 头孢曲松 预处理 胶质细胞 炎症反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]