通窍活血汤联合盐酸氟桂嗪治疗椎基底动脉供血不足性眩晕瘀血阻窍证临床研究  

Clinical research of Tongqiao-Huoxue decoction for the treatment of vertebrobasilar artery insufficiency vertigo with stasis orifice type

作　　者：狄永良 杨志洁 Di Yongliang;Yang Zhijie(Department of Pharmacy,Liyang Hospital of Traditional Chinese Medicine,Liyang 213300,China)

机构地区：[1]江苏省溧阳市中医医院药剂科,213300

出　　处：《国际中医中药杂志》2019年第4期339-342,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的评价通窍活血汤联合盐酸氟桂嗪治疗瘀血阻窍证椎基底动脉供血不足性眩晕的疗效。方法将符合入选标准的93例患者采用随机数字表法分为对照组46例和研究组47例。对照组口服盐酸氟桂嗪,研究组在对照组基础上加服通窍活血汤。2组均连续治疗4周。采用TCD检测左侧椎动脉(left vertebral artery,LVA)、右侧椎动脉(right vertebral artery,RVA)及基底动脉(basil arartery,BA)平均血流速度,采用彩色多普勒超声仪检测血液流变学指标,采用全自动生化分析仪检测血清TC、TG、LDL-C、HDL-C水平,评价临床疗效。结果研究组总有效率为93.6%(44/47)、对照组为78.3%(36/46),2组比较差异有统计学意义(χ^2=4.559,P=0.033)。治疗后,研究组LVA[(38.34±3.72)cm/s比(29.73±3.11)cm/s,t=12.096]、RVA[(41.12±4.05)cm/s比(34.11±3.86)cm/s,t=8.541]、BA[(48.92±5.24)cm/s比(40.75±4.63)cm/s,t=7.962]平均血流速度均大于对照组(P<0.01);研究组全血黏度、血浆黏度、红细胞聚集指数及纤维蛋白原含量均低于对照组(t值分别为5.457、8.875、3.661、6.549,P值均<0.01);研究组血清TC、TG、LDL-C水平均低于对照组(t值分别为3.838、6.369、5.201,P值均<0.01),血清HDL-C水平高于对照组(t=4.836,P<0.01)。结论通窍活血汤联合盐酸氟桂嗪可增加瘀血阻窍证椎基底动脉供血不足性眩晕患者的脑部血流量,改善血液流变学和血脂水平。Objective To investigate the clinical application of Tongqiao-Huoxue decoction for the treatment of vertebrobasilar artery insufficiency vertigo with stasis orifice type. Methods According to the random table method, 93 vertebrobasilar artery insufficiency vertigo patients with stasis orifice type were divided into the control group (n=46) and the treatment group (n=47). The patients in the control group were treated with fluoguizine hydrochloride, while the patients in the treatment group were treated with Tongqiao-Huoxue decoction on the basis of control group. Two groups were treated for 4 weeks. The clinical total effective rate of two groups of patients after treatment was compared. The LVA mean blood flow velocity, RVA mean blood flow velocity, BA mean blood flow velocity, total blood viscosity, plasma viscosity, erythrocyte aggregation index, fibrinogen, TC, TG, LDL-C and HDL-C were detected respectively before and after treatment. In addition, the adverse reaction incidence of two groups of patients were observed. Results The total effective rate of treatment group was 93.6%(44/47), while the total effective rate of control group was 78.3%(36/46). The difference between two groups was statistically significant (χ^2=4.559, P=0.033). After treatment,the LVA mean blood flow velocity (38.34 ± 3.72 cm/s vs. 29.73 ± 3.11 cm/s, t=12.096), RVA mean blood flow velocity (41.12 ± 4.05 cm/s vs. 34.11 ± 3.86 cm/s, t=8.541),BA mean blood flow velocity (48.92 ± 5.24 cm/s vs. 40.75 ± 4.63 cm/s, t=7.962), HDL-C (2.13 ± 0.64 mmol/L vs. 1.54 ± 0.53 mmol/L, t=4.836) of treatment group were significantly higher than the control group (P<0.05), while the total blood viscosity, plasma viscosity, erythrocyteaggregation index, fibrinogen, TC, TG, LDL-C of treatment group were significantly lower than the control group (t value were 5.457, 8.875, 3.661, 6.549, 3.838, 6.369, 5.201, all Ps<0.05). No serious adverse reactions occurred during the treatment of the two groups. Conclusions The clinical curative effect of Tongqia

关 键 词：眩晕 椎底动脉供血不足 通窍活血汤 盐酸氟桂嗪胶囊 瘀血阻窍证 

分 类 号：R741[医药卫生—神经病学与精神病学]