结直肠癌Ang-2和CD147的水平及其对预后的预测价值  

Level of Ang-2 and CD147 in Colorectalcancer and Their Value in Prognosis Prediction

作　　者：丛玲华 钟国平 陈鲧 方来福 李萍 Cong Linghua;Zhong Guoping;Chen Wei(Department of Pathology, Ningbo Yinzhou People′s Hospital, Zhejiang 315040, China)

机构地区：[1]宁波市鄞州人民医院病理科

出　　处：《医学研究杂志》2019年第4期83-87,共5页Journal of Medical Research

基　　金：浙江省宁波市科技计划项目(2015-18)

摘　　要：探讨结直肠癌患者促血管生成素Ⅱ(angiopoietin-2,Ang-2)和簇分笔者医化抗原147 (cluster of differentiation 147,CD147)的水平及其对预后的预测价值。方法:回顾性分析2012年6月~2016年5月笔者医院诊治的260例结直肠癌患者,根据随访结果分为生存组( n =215)和死亡组( n =45),并选择50例结直肠息肉作为对照组,均应用组织芯片技术进行免疫组化结果分析,比较Ang-2和CD147不同表达水平间临床和病理表现的差异及对预后的预测价值。结果:结直肠癌组与对照组患者的年龄、性别、BMI和既往史之间比较差异无统计学意义( P >0.05)。结直肠癌组患者Ang-2及CD147表达水平明显高于对照组( P =0.000)。生存组与死亡组患者的年龄、性别、BMI和既往史之间比较差异无统计学意义( P >0.05)。生存组与死亡组患者的肿瘤部位、病理类型、分化程度、临床分期及治疗方式等资料间比较差异无统计学意义( P >0.05);生存组Ang-2及CD147表达分值明显低于死亡组( P =0.000),淋巴结转移情况明显低于死亡组( P =0.000)。ROC曲线显示,应用Ang-2及CD147表达水平对预测结直肠癌患者预后具有较高的诊断效能,其AUC分别为0.821和0.788,差异无统计学意义(P >0.05);Youden 指数提示Ang-2及CD147表达水平预测结直肠癌患者预后的最佳截点分别为≥4分和≥3分。Ang-2及CD147表达水平预测结直肠癌患者预后的诊断准确率(81.88%,83.33%)、敏感度(81.30%,82.00%)、特异性(83.33%,87.69%)和阳性预测值(87.23%,89.23%)比较,差异无统计学意义( P >0.05)。结论:结直肠癌患者Ang-2和CD147表达水平较高,Ang-2和CD147在预测结直肠癌患者预后中有较高价值,Ang-2≥4分和CD147≥3分可作为提示不良预后的参考指标。To explore the level of Ang-2 and CD147 in colorectalcancer patients and their value in prognosis prediction. Methods A retrospective analysis of 260 patients with colorectal cancer diagnosed in our hospital from June 2012 to May 2016 was divided into survival group (215 cases) and death group (45 cases) according to the follow-up results, and 50 cases of colorectal polyps were selected. In the control group, tissue microarray technique was used to analyze the results of immunohistochemistry. The clinical and pathological findings of different expression levels of Ang-2 and CD147 were compared and the prognostic value was compared. Results No significant difference in age, gender, BMI and previous history were found between colorectalcancer group and control group( P >0.05). The expression level of Ang-2 and CD147 in colorectal cancer group was significantly higher than those in control group( P =0.000).No significant difference in age, gender, BMI and previous history were found between survival group and death group( P >0.05).No significant difference of tumor location, pathological type, differentiated degree,clinical stage and treatment methods was found among survival group and death group( P >0.05). Expression scores of Ang-2 and CD147 in survival group were significantly lower than those in death group( P =0.000). The lymph node metastasis in survival group was significantly lower than those in death group( P =0.000). The ROC curve showed that Ang-2 and CD147 has high value in predicting the prognosis of colorectal cancer patients (AUC=0.821, 0.788), of which the best cut-off point for Ang-2 was ≥4 point and CD147 was ≥3 point. There was no significant difference in the diagnostic accuracy(81.88%,83.33%), sensitivity(81.88%,83.33%), specificity(83.33%,87.69%) and positive predictive value(87.23%,89.23%) of Ang-2 and CD147 in predicting the prognosis of colorectal cancer patients. Conclusion The expression level of Ang-2 and CD147 tend to be higher in colorectal cancer patients. Ang-2 and CD147 is valua

关 键 词：ANG-2 CD147 结直肠癌预后 

分 类 号：R735.3[医药卫生—肿瘤]