间叶软骨肉瘤四例临床病理分析  

Clinicopathologic analysis of four cases in mesenchymal chondrosarcoma

作　　者：叶丽娟[1] 袁婧 李鹍[2] 范耀东[3] 徐开敏[1] YE Li-juan;YUAN Jing;LI Kun;FAN Yao-dong;XU Kai-min(Yunnan Tumor Hospital ,Yunnan 650118,P. R. China)

机构地区：[1]云南省肿瘤医院病理科,云南昆明650118 [2]云南省肿瘤医院影像科,云南昆明650118 [3]云南省肿瘤医院神经外科,云南昆明650118

出　　处：《中华肿瘤防治杂志》2019年第7期516-519,共4页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的间叶软骨肉瘤(mesenchymal chondrosarcoma,MC)较为罕见,本研究探讨MC的临床、影像及病理特征。方法选取云南省肿瘤医院收治的4例MC患者,分析其病理学资料,结合临床和影像学特征,分析MC的病理学特征并复习相关文献。结果 4例MC患者,男女各2例;平均年龄36岁;2例来自骨组织,1例软组织,1例中枢神经系统。CT和MR示,病灶边缘不清,见斑点状钙化,周围软组织肿块形成。病理学镜检示,由密集的原始小细胞和分化性软骨岛两种成分组成。免疫表型示,小细胞CD99、Syn、CgA、vimentin及CD56均阳性(+),软骨岛S-100阳性(+)。结论 MC诊断需结合临床、影像和病理学资料,应与含小细胞或软骨成分的其他肿瘤鉴别。OBJECTIVE To investigate the clinical,imaging,pathological and immunophenotypic characteristics of mesenchymal chondrosarcoma(MC).METHODS Four cases of MC were stained by HE and EnVision immunohistochemical method.Combined with their clinical data and imaging findings,we analyzed the histopathological features of MC and reviewed related literatures.RESULTS There were 4 cases of mesenchymal chondrosarcoma,2 males and 2 females.The average age was 36 years,2 cases were from bone tissue,1 cases originated from soft tissues,and 1 cases came from central nervous system.Imaging findings showed unclear edge of lesion,fine spotted calcification of tumor.Microscopic examination showed it consists of two components of high-abundance of immature small cells and highly differentiated hyaline cartilage islands.Immunophenotype showed CD99,Syn,CgA,vimentin and CD56 were positive in small cells;S-100 was positive in cartilage component.CONCLUSION MC is a rare clinical subtype of chondrosarcoma,combined with clinical,imaging and immunohistochemical markers,and molecular characteristics are helpful for differential diagnosis with other malignant tumor containing small cell or chondro tissue.

关 键 词：骨肿瘤 间叶软骨肉瘤 病理诊断 鉴别诊断 

分 类 号：R738.3[医药卫生—肿瘤]