纳米拉曼影像在肿瘤诊疗中的应用  

Surface-enhanced Raman nanoparticles for cancer theranostics

作　　者：李鑫[1] 李杨杨[2] 刘凤永[1] 周民 王茂强[1] Li Xin;Li Yangyang;Liu Fengyong;Zhou Min;Wang Maoqiang(Department of Interventional Radiology,General Hospital of PLA,Beijing 100853,China;Institute of Translational Medicine,Department of Nuclear Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310029,China)

机构地区：[1]解放军总医院介入放射科,北京100853 [2]浙江大学转化医学研究院、浙江大学医学院附属第二医院核医学科,杭州310029

出　　处：《中华核医学与分子影像杂志》2019年第4期241-243,共3页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家自然科学基金面上项目(81671800);北京市自然科学基金面上项目(7172204).

摘　　要：拉曼光谱可被具有表面增强拉曼散射效应的纳米粒子(SERS-NPs)放大,通过SERS-NPs可实现对拉曼信号的增强,实现肿瘤的高分辨率成像。SERS-NPs具有高度分子特异性和灵敏度等特点,在肿瘤诊疗中展现出良好的应用前景。该文从SERS-NPs的优势、肿瘤诊疗应用及相关研究等方面进行综述。Raman spectroscopy is amplified by surface-enhanced Raman scattering nanoparticles (SERS-NPs), and Raman signal can be enhanced by SERS-NPs, which can achieve high-resolution imaging of tumors. Meanwhile, SERS-NPs have high molecular specificity and sensitivity, showing a good prospect of tumor diagnosis and treatment. The advantages of SERS-NPs and its application in tumor diagnosis and treatment, and related experimental studies are reviewed in this article.

关 键 词：光谱分析 拉曼 诊疗纳米医学 肿瘤 发展趋势 

分 类 号：R730.4[医药卫生—肿瘤]