结肠癌组织中错配修复蛋白表达及其对患者预后的影响  

Analysis of mismatch repair status in relation to clinicopathological characteristics and prognosis in colon cancer

作　　者：王超[1] 高志冬[1] 姜可伟[1] 杨晓东[1] 梁斌[1] 申占龙[1] 沈凯[1] 郭鹏[1] 曹键[1] 崔艳成[1] 尹慕军[1] 王杉[1] 叶颖江[1] Wang Chao;Gao Zhidong;Jiang Kewei;Yang Xiaodong;Liang Bin;Shen Zhanlong;Shen Kai;Guo Peng;Cao Jian;Cui Yancheng;Ying Mujiin;Wang Shan;Ye Yingjiang(Department of Gastrointestinal Surgery,Peking University People's Hospital, Laboratory of Surgical Oncology,Peking University People's Hospital ,Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research ,Beijing 100044 China)

机构地区：[1]北京大学人民医院胃肠外科北京大学人民医院外科肿瘤实验室,北京市结直肠癌诊疗研究重点实验室,100044

出　　处：《中华普通外科杂志》2019年第4期349-352,共4页Chinese Journal of General Surgery

基　　金：北京市科技计划项目(Z161100000516104).

摘　　要：目的 探讨结肠癌组织中错配修复蛋白缺失(mismatch repair deficient,MMR-deficient)与临床病理特征的关系及其对患者预后的影响.方法 收集北京大学人民医院胃肠外科2012年11月至2016年3月行开腹结肠癌根治术的299例结肠癌患者的临床病理资料,采用多因素Logistic回归分析MMR-deficient与临床病理特征的相关因素,并用Kaplan-Meier生存曲线分析MMR-deficient对结肠癌患者预后的影响.结果 299例结肠癌组织中MMR-deficient率为17.1%.单因素分析结果显示:年龄< 70岁(χ^2=4.582,P=0.032)、低分化(χ^2=8.054,P=0.005)、右半结肠癌(χ^2=18.253,P<0.001)、黏液腺癌(χ^2=6.257,P=0.012)、癌结节(P=0.019)、无淋巴结转移(χ^2=9.418,P=0.002)、术后UICC分期Ⅰ~Ⅱ期(χ^2=10.672,P=0.001)均与MMR-deficient有关.多因素分析结果发现,低分化结肠癌(OR=3.555,95% CI:1.685 ~7.640,P<0.001)、右半结肠癌(OR=5.645,95% CI:2.483~ 14.715,P<0.001)及UICC分期Ⅰ~Ⅱ期结肠癌(OR=4.099,95% CI:1.863 ~9.840,P<0.001)为MMR-deficient的独立影响因素.结论 MMR-deficient更常见于低分化结肠癌、右半结肠癌和UICC分期Ⅰ~Ⅱ期结肠癌.Objective To investigate the influence of mismatch repair status on clinicopathological characteristics and prognosis in patients with colon cancer.Methods Patients who underwent radical excision for colon cancer between Nov 2012 and Mar 2016 at Peking University People's Hospital were enrolled.Clinicopathological data and prognosis were collected.Multivariate analysis were used to identify independent characteristics of MMR-deficient colon cancer.The influence of MMR-deficient on prognosis of colon cancer were analyzed through Kaplan-Meier curve.Results The overall rate of MMR-deficient in colon cancer was 17.1% (51/299).Multivariate logistic regression analysis showed that low differentiation (OR =3.555,95% CI:1.685-7.640,P < 0.001),right-sided colon cancer (OR =5.645,95% CI:2.483-14.715,P < 0.001) and UICC Stage Ⅰ-Ⅱ (OR =4.099,95% CI:1.863-9.840,P <0.001) were associated with MMR-deficient colon cancer.Conclusion Low differentiation,right-sided colon cancer and UICC Stage Ⅰ-Ⅱ were more common in MMR-deficient colon cancer.

关 键 词：结肠肿瘤 预后 错配修复蛋白 

分 类 号：R735.35[医药卫生—肿瘤]