阿替普酶静脉溶栓对脑梗死后认知功能障碍的保护作用研究  

Study on the Protective Effect of Intravenous Thrombolysis of Alteplase on Cognitive Dysfunction after Cerebral Infarction

作　　者：何柳[1] 王蕾[1] 张仲[1] 姜帅[1] 方升[1] 徐广会 HE Liu;WANG Lei;ZHANG Zhong;JIANG Shuai;FANG Sheng;XU Guang-hui(Chengdu Third People's Hospital,Chengdu 610031,China)

机构地区：[1]成都市第三人民医院,四川成都610031

出　　处：《中国医药指南》2019年第10期2-3,共2页Guide of China Medicine

基　　金：成都市科技局科技惠民技术研发项目(2015-HM01-00240-SF)(基金名称:急性缺血性卒中溶栓流程优化的应用研究)

摘　　要：目的探讨脑梗死采用阿替普酶静脉溶栓治疗对认知功能障碍的影响。方法连续收集2014年7月至2017年8月在我院神经内科收治的超早期脑梗死并且经评估接受了rt-PA静脉溶栓治疗的患者作为研究对象,最后327例纳入分析。所有研究对象均给予rt-PA(德国勃林格殷格翰药业公司生产)标准化静脉溶栓治疗。分别于入院第3天与出院后3个月采用MMSE评定量表与MoCA评定量表对患者认知功能进行评价。结果在不同文化程度患者中,出院后3个月,患者MMSE、MoCA评定为认知障碍率均得到显著下降,差异有统计学意义(P <0.05)。结论脑梗死采用阿替普酶静脉溶栓治疗能够显著改善患者认知功能预后。Objective To explore the effect of intravenous thrombolytic therapy with alteplase on cognitive dysfunction in cerebral infarction. Methods Patients with ultra-early cerebral infarction treated in the department of neurology of our hospital from July 2014 to August 2017 were successively collected and evaluated to receive rt-pa intravenous thrombolysis as subjects, and 327 cases were included for analysis. All subjects were given rt-pa (produced by beringer ingelheim pharmaceutical co., Germany) standard intravenous thrombolysis. The MMSE rating scale and MoCA rating scale were used to evaluate the cognitive function of patients on the 3rd day of admission and 3 months after discharge respectively. Results Among patients with different levels of education, the rate of cognitive impairment assessed by MMSE and MoCA was significantly decreased 3 months after discharge, with statistically significant differences (P <0.05). Conclusion Intravenous thrombolytic therapy with alteplase can significantly improve the prognosis of patients with cerebral infarction.

关 键 词：阿替普酶 静脉溶栓 脑梗死 认知功能障碍 

分 类 号：R743.34[医药卫生—神经病学与精神病学]