不同放疗靶区对食管癌疗效及不良反应的Meta分析  

Meta-analysis of the Efficacy and Side Effects of Different Radiotherapy Target on Esophageal Cancer

作　　者：田新学 高园园 康小红[1] 崔艳慧[1] 王颖[1] 苗战会[1] TIAN Xin-xue;GAO Yuan-yuan;KANG Xiao-hong;CUI Yan-hui;WANG Ying;MIAO Zhan-hui(Department of Oncology,the First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,China)

机构地区：[1]新乡医学院第一附属医院肿瘤科,河南卫辉453100

出　　处：《中国医药指南》2019年第13期28-30,共3页Guide of China Medicine

摘　　要：目的不同放疗靶区对食管癌近期疗效及不良反应的对比分析。方法检索2005年1月1日至2017年6月1日放疗不同靶区对食管癌的临床随机对照研究(RCT)文献,对收集的文献进行评价,对符合本研究纳入标准的文献采用RevMan5.3软件进行统计学分析。结果共纳入9篇RCT,包括685例患者,试验组(淋巴引流区预防照射组)343例,对照组(累及野组)342例。Meta分析结果表明,1年生存率95%CI值为0.99,P>0.05,3年生存率95%CI值为1.31,P=0.20;均无统计学意义;1年局控率95%CI值为0.91,P>0.05,无统计学意义;放射性肺炎95%CI值为2.16,P<0.05,差异具有统计学意义;放射性食管炎95%CI值为2.76,P<0.05,差异具有统计学意义。结论在食管癌放疗不同靶区勾画中,试验组与对照组比较,试验组并不能改善患者的1、3年生存率和1年局控率,反而增加放射性肺炎和放射性食管炎的发生率。Objective To evaluate the clinical efficacy and toxicities of the radiotherapy for esophageal carcinoma by analyzing the different clinical target volume. Methods To search the clinical randomized controlled trials from January 2005 to June 2017 in the treatment of esophageal cancer treated with different clinical target volume. The trials were collected and evaluated. The meta-analysis was performed for the results by RevMan 5.3 software. Results Participants include 9 RCT, total 685 patients, including 343 patients in the intervention group (elective nodal irradiation group) and 342 patients in the usual care group(involved-field irradiation group). There were no statistically significant difference in 1 year survival rate 95%CI was 0.99, P >0.05, 3 year survival rate 95%CI was 1.31, P =0.20;the similar results also were found in 1 year locoregional control rate 95%CI was 0.91 ,P >0.05. However the radioactive pneumonia, radiation esophagitis had statistical significant difference with 95%CI 2.16, P <0.05, and 95%CI 2.76, P <0.05, respectively. Conclusion Compared with control group (involved-field irradiation group), the intervention group (elective nodal irradiation group) did not improve 1 year survival rate and 1 year locoregional control rate of patients, but increased higher incidence of radioactive pneumonia and radiation esophagitis in patients.

关 键 词：食管癌 放疗 累及野 淋巴引流区 

分 类 号：R735.1[医药卫生—肿瘤]