北京市某社区95例精神病患者健康体检肝功能指标异常情况分析  

Analysis of abnormal liver function indicators of 95 psychiatric patients in a community of Beijing

作　　者：李熹娟 丁常娥 杨建柳 LI Xi-juan;DING Chang-e;YANG Jian-liu(Beijing Haidian District Ganjiakou Community Health Service Center,Beijing 100037, China)

机构地区：[1]北京市海淀区甘家口社区卫生服务中心,100037

出　　处：《中国实用医药》2019年第12期21-23,共3页China Practical Medicine

摘　　要：目的了解北京市某社区精神病患者健康体检肝功能指标异常情况,以便为该群体的健康指导提供科学依据。方法选取95例严重精神病患者作为研究对象,采集静脉血,分离收集血清,采用全自动生化检测仪检测肝功能指标,包括丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)活性、总胆红素(TBIL)、直接胆红素(DBIL)含量。分析患者单项肝功能指标出现异常情况,比较不同性别、不同年龄的ALT、AST、DBIL、TBIL异常情况。结果 95例患者单项肝功能指标出现异常者55例(57.89%);其中血清ALT异常17例(17.89%)、AST异常3例(3.16%)、TBIL异常15例(15.79%)、DBIL异常20例(21.05%)。男性患者TBIL异常发生率高于女性,差异有统计学意义(P<0.05);男性与女性ALT、AST、DBIL异常发生率比较差异无统计学意义(P>0.05)。≤40岁患者的ALT异常发生率高于41～59岁患者,差异有统计学意义(P<0.05)。结论该社区精神病患者健康体检中肝功能指标异常的发生率较高,应加强相关指标的动态检测,并结合临床给予健康指导,以利于该群体的健康维护。Objective To understand the abnormalities of liver function indicators in the physical examination of mental patients in a community in Beijing, in order to provide a scientific basis for the health guidance of this group. Methods A total of 95 patients with severe mental illness were selected as the study subjects. The venous blood of the patients was collected, and serum was separated and collected. The liver function indexes were detected by automatic biochemical detector, including alanine aminotransferase(ALT) and aspartate aminotransferase(AST) activity, total bilirubin(TBIL), direct bilirubin(DBIL) content. The abnormalities of individual liver function indexes were analyzed, and the abnormalities of ALT, AST, DBIL and TBIL in different gender and age were compared. Results Among 95 patients, 55 cases(57.89%) had abnormal liver function indices, 17 cases(17.89%) had abnormal serum ALT, 3 cases(3.16%) had abnormal AST, 15 cases(15.79%) had abnormal TBIL and 20 cases(21.05%) had abnormal DBIL. The incidence of abnormal TBIL in male patients was higher than that in female patients, and the difference was statistically significant(P<0.05). The incidence of abnormal ALT, AST and DBIL in male and female was not statistically significant(P>0.05). The incidence of abnormal ALT in patients ≤ 40 years old was higher than that in patients aged 41~59 years old, and the difference was statistically significant(P<0.05). Conclusion The incidence of abnormal liver function indicators is high in the community psychiatric patients during health examination. Dynamic detection of related indicators should be strengthened, and health guidance should be given in combination with clinical practice, so as to facilitate the health maintenance of this group.

关 键 词：肝功能 体格检查 精神病 

分 类 号：R749[医药卫生—神经病学与精神病学]