儿童血型B抗原性减弱的初步分析及探讨  

Preliminary analysis and discussion on the decrease of antigenicity of blood group B in children

作　　者：任晓艳 马玲[2] 孙文杰[1] 冯丽[1] 李萌[1] REN Xiaoyan;MA Ling;SUN Wenjie;FENG Li;LI Meng(Clinical Laboratory Department ,Children's Hospital of Nanjing Medical University, Nnajiing 210008,China;Jiangsu Blood Center)

机构地区：[1]南京医科大学附属儿童医院检验科,江苏南京210008 [2]江苏省血液中心输血研究室

出　　处：《中国输血杂志》2019年第2期166-168,共3页Chinese Journal of Blood Transfusion

基　　金：南京市医学科技发展项目(YKK17159)

摘　　要：目的探讨儿童血型B抗原减弱的原因,以期对今后儿童血型的分子机制进一步研究提供试验性数据。方法对本院2015年6月—2017年1月3例不同年龄段患儿B抗原性减弱的标本进行血清学和Sanger双脱氧DNA分子测序分析。结果 3例B抗原性减弱标本均为亚型;其中1例Bx型,2例Bw型。结论儿童血型B抗原减弱有可能是亚型造成,在儿童血型鉴定时尤其要重视。Objective To explore the reason why the blood type B antigen is weakened in children and to provide experimental data for further research on the molecular mechanism of children′s blood type in the future.Methods From June 2015 to January 2017, 3 blood samples with weakened B blood group antigens from children of different ages were analyzed by serology and Sanger double-base DNA sequencing. Results Three cases with weakened B blood group antigens were all subtypes;one case was Bx type, and the other two cases were Bw type. Conclusion The decrease of antigenicity of blood group B in children may be caused by subtypes, and particular attention should be paid in the identification of children′s blood typing.

关 键 词：儿童血型 B抗原减弱 血清学检测 基因测序 

分 类 号：R457.11[医药卫生—治疗学]