CHFR基因甲基化与消化道肿瘤发生及对化疗药物敏感性的研究新进展  

Recent advances in methylation of CHFR gene,digestive oncogenesis and chemosensitivity to chemotherapeutic drugs

作　　者：陈苗 冯立[2] 邢智[2] CHEN Miao;FENG Li;XING Zhi(Graduate School,Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学研究生院,呼和浩特110000 [2]内蒙古医科大学附属人民医院胃肠外科

出　　处：《疑难病杂志》2019年第5期528-531,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：内蒙古医科大学科技百万工程项目[TKD2016KJBW(LH)027]

摘　　要：CHFR是一个新的有丝分裂前期检查点基因,同时也是一种新发现的抑癌基因。研究发现CHFR在正常组织中广泛表达,在癌组织中却频繁缺失,而启动子CpG岛的甲基化是导致CHFR表达缺失或沉默的重要机制,由此而引发肿瘤的发生。文章将对CHFR基因甲基化与消化道肿瘤的发生以及对化疗药物敏感性的研究进展作一综述。The CHFR is a new pre-mitotic checkpoint gene and a new cancer suppressor gene. It has been found that CHFR is widely expressed in normal tissues, but frequently absent in cancer tissues. Methylation of promoter CpG islands is an important mechanism leading to the absence or silence of CHFR expression, which leads to tumorigenesis. This article reviews the methylation of CHFR gene, the occurrence of digestive tumors and the research progress of chemosensitivity.

关 键 词：CHFR基因 甲基化 肿瘤 化疗敏感性 

分 类 号：R735[医药卫生—肿瘤]