CLIPPERS综合征一例并文献复习  

A case report of CLIPPERS syndrome and literature review

作　　者：武翠梅 王改青[1] Wu Cuimei;Wang Gaiqing(Department of Neurology,Second Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学第二医院神经内科,太原市030000

出　　处：《中国脑血管病杂志》2019年第5期266-268,共3页Chinese Journal of Cerebrovascular Diseases

摘　　要：类固醇激素反应性慢性淋巴细胞性炎性反应伴脑桥血管周围强化症(CLIPPERS)综合征是一种对类固醇激素治疗敏感的慢性中枢神经系统炎性疾病,主要累及脑桥,部分患者也可同时累及多个部位。该病比较罕见,其诊断主要依据头部MR增强扫描示"胡椒盐"样强化这一特殊的影像学改变及结合临床中其他检查手段进行诊断,需与临床表现及影像学改变与CLIPPERS综合征类似的疾病进行鉴别,给予激素治疗后可有效缓解临床症状。作者报道1例主要累及小脑和脊髓的CLIPPERS综合征,以加强对该病的认识。Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids(CLIPPERS syndrome) is a chronic central nervous system inflammatory disease with sensitivity to steroid therapy.It mainly involves the pons and sometimes other sites.It is relatively rare,and diagnosed by the special sign of ‘pepper-salt-like enhancement’ in the head magnetic resonance imaging combining other clinical examinations.It should be differentiated from diseases with similar imaging changes.Steroid therapy can effectively relieve the clinical symptoms.The authors report a case of CLIPPERS syndrome that mainly involving cerebellum and spinal cord,and that will be helpful for the understanding of this disease.

关 键 词：CLIPPERS综合征 小脑 脊髓 

分 类 号：R742[医药卫生—神经病学与精神病学]