Survivin在肾细胞癌中的表达及临床意义  

The Expression and clinical Significance of Survivin in renal cell carcinoma

作　　者：秦松林[1] 刘婷 胡威 刘伯龙[1] 唐正[1] 赵磊[3] Qing Songlin;Liu Ting;Hu Wei;Liu Bolong;Tang Zheng;Zhao Lei(Department of Urology male, the First Affiliated Hospital of Nanhua University, Hengyang 421001, China;Department of Surgery Center, the First Affiliated Hospital of Nanhua University, Hengyang 421001, China;Department of Gastrointestinal surgery, the First Affiliated Hospital of Nanhua University, Hengyang 421001, China)

机构地区：[1]南华大学附属第一医院泌尿男科,衡阳421001 [2]南华大学附属第一医院手术中心,衡阳421001 [3]南华大学附属第一医院胃肠外科,衡阳421001

出　　处：《国际泌尿系统杂志》2019年第3期483-486,共4页International Journal of Urology and Nephrology

基　　金：湖南省自然科学基金面上项目(2016JJ2109);湖南省教育厅一般项目(17C1382)。

摘　　要：目的探讨Survivin在肾细胞癌发生、发展中的作用和意义,分析其表达与肾细胞癌生物学行为(临床分期、病理分级及淋巴转移)之间的关系。方法选取2010年3月至2011年9月在中南大学湘雅三医院治疗的肾细胞癌患者26例,免疫组化检测了肾细胞癌和癌旁正常肾组织中Survivin蛋白的表达情况,并将Survivin蛋白表达结果与肾细胞癌的临床分期、病理分级和淋巴转移等进行相关性分析。结果26例肾癌组织中Survivin蛋白的阳性表达为19例(73.1%),阴性表达为7例(26.9%),16例正常肾组织中未见阳性表达,组间比较差异具有统计学意义(P<0.05)。Survivin蛋白在Ⅰ、Ⅱ期肾细胞癌11例患者中阳性表达患者共有5例(45.5%),在Ⅲ、Ⅳ期肾细胞癌15例患者中阳性表达14例(93.3%),组间比较差异具有统计学意义(P<0.05)。Survivin蛋白在中低分化肾细胞癌13例中阳性表达12例(92.3%),在高分化肾细胞癌13例患者中阳性表达7例(53.8%),差异具有统计学差异(P<0.05)。Survivin蛋白在有淋巴结转移的肾细胞癌患者中阳性表达率为93.3%(14/15),在无淋巴结转移的肾细胞癌患者中阳性表达率为45.5%(5/11)。两组间比较差异具有统计学意义(P<0.05)。Survivin在肾癌中的表达与患者的年龄、性别差异均无统计学意义。结论Survivin在肾细胞癌中高表达,而在正常的肾脏组织中不表达。Survivin有望成为判断肾癌转移和预后等生物学行为的重要指标,将有可能成为肿瘤治疗的新靶点。Objective To investigate the effect and significance of Survivin oncogenesis and progression on renal cell carcinoma, and the relationship between Survivin expression and biology behavior(clinical stages, pathological grades and lymphatic metastases)of renal cell carcinoma, providing evidence for diagnosis, therapy and prognosis of renal cell carcinoma. Methods Immunohistochemical analysis was performed to detect the Survivin protein, then carrying out relative analyses between survivin protein expression and clinical stage, pathological grade and lymphatic metastases of renal cell carcinoma. All statistical analyses were carried out with SPSS 21.0 software. The probability of less than 5% was assumed to be statistically significant (P<0.05). Results ①The positive rate of Survivin protein expression on the renal cell carcinoma was 73.1%(19/26), and the positive expression of Survivin wasn't found in the normal renal tissues(0/16). Survivin expressions in renal cell carcinoma were significantly higher than those in normal renal tissues, there was significant difference(P<0.05).②In stage I-II, the positive rate of Survivin protein was 45.5%(5/11). In stage III-IV, the positive rate of Survivin protein was 93.3%(14/15). There was significant difference between the two groups (P<0.05). There was significant difference between the two groups (P<0.05).③In the poorly differentiated group and the differentiation group, the positive rate of Survivin protein expression was 92.3%(12/13). In the well-differentiated group, the positive rate of Survivin protein expression was 53.8%(7/13). There was significant difference between the two groups (P<0.05). There was significant difference between the two groups (P<0.05).④The positive rate of Survivin protein expression was 93.3%(14/15) in patients with lymph node metastasis and 45.5%(5/11) in those without.There was significant association between expression of Survivin protein and metastasis(P<0.05).⑤There was no association between the expression of Survivin and ages

关 键 词：肾肿瘤 凋亡抑制蛋白质类 

分 类 号：R737.11[医药卫生—肿瘤]