细胞自噬在神经胶质瘤治疗中的研究进展  

Research progress on autophagy in treatment of glioma

作　　者：王京萍 曾令公 武世伍[1] 马莉[1] 柴大敏[1] WANG Jing-ping;ZENG Ling-gong;WU Shi-wu;MA Li;CHAI Da-min(Department of Clinical Pathology,The First Affiliated Hospital,Department of Pathology,Bengbu Medical College,Bengbu 233000,China)

机构地区：[1]蚌埠医学院第一附属医院临床病理科蚌埠医学院病理学教研室,安徽蚌埠233000

出　　处：《中国病理生理杂志》2019年第5期955-960,共6页Chinese Journal of Pathophysiology

基　　金：安徽省高校自然科学重点项目(No.KJ2016A460);安徽省高校优秀青年人才支持计划重点项目(No.gxyq2017032);蚌埠医学院自然科学基金资助项目(No.BYKF1708ZD);蚌埠医学院研究生科研创新计划(No.Byycx1839)

摘　　要：1 自噬概述"Autophagy"即自噬,这个词是de Duve等[1]于1966年发现溶酶体的同时创造出来的,描述的是具有单层或双层膜的结构吞噬受损的蛋白质和细胞器等功能失调的细胞组分形成自噬体,之后与溶酶体融合形成自噬溶酶体,最后将包裹物降解的一个过程。通过自噬降解的包裹物包括糖、核苷酸、氨基酸和脂肪酸,最终自噬体会同溶酶体进行融合进而将细胞器降解,这一过程可以为细胞提供大量的营养物质以及用于细胞再生的结构基础。Autophagy is a transport pathway from the cytoplasm to the lysosome, which is a major intracellular degradation/recycling system ubiquitous in eukaryotic cells. Autophagy regulation has achieved some gratifying results in the treatment of glioma. It is currently an exciting field of clinical development. In chemotherapy or radiotherapy, autophagy-related drugs are currently used in vitro and in vivo for treating tumors with significant effects. Autophagy inducers and inhibitors may potentially block tumor formation and enhance the anti-cancer immune response. A more comprehensive understanding of the role of autophagy in different stages of glioma development may guide the development of new therapeutic strategies.

关 键 词：自噬 神经胶质瘤 替莫唑胺 氯喹 PI3K/Akt/mTOR信号通路 

分 类 号：R739.41[医药卫生—肿瘤] R363[医药卫生—临床医学]