奥卡西平对儿童病毒性脑炎继发癫痫患者的炎性因子、免疫功能及氧化应激的影响  

Effect of oxcarbazepine on immune function,inflammatory factor and oxidative stress of children patient with epilepsy secondary to viral encephalitis

作　　者：夏顺刚[1] 卢红[1] XIA Shun-Gang;LU Hong(Maternal and Child Health Hospital of Zibo,Zibo 255029,China)

机构地区：[1]淄博市妇幼保健院儿科,淄博255029

出　　处：《中国免疫学杂志》2019年第9期1122-1125,共4页Chinese Journal of Immunology

摘　　要：目的:了解奥卡西平药物对儿童病毒性脑炎继发癫痫患者、炎性因子、免疫功能及机体氧化应激的影响。方法:选取确诊为病毒性脑炎继发癫痫患者59例作为实验组,35例健康者作为对照组;实验组患者口服奥卡西平片治疗8个月;观察奥卡西平治疗儿童病毒性脑炎继发癫痫的效果,检测治疗前后及对照组的血清炎性因子(IL-1β、IL-8、IL-6及TNF-α)水平及CD3^+、CD4^+、CD8^+等T细胞亚群的变化。同时,观察奥卡西平对机体氧化应激指标(ROS,SOD和MDA)的影响。结果:奥卡西平治疗病毒性脑炎继发癫痫的有效率达到83. 05%。实验组患者治疗前IL-8、IL-6、TNF-α、CD8+T细胞、ROS及MDA均高于对照组(P<0. 05),治疗后这些指标都有显著降低(P<0. 05),但仍然高于对照组(P<0. 05);患者的CD3^+、CD4^+T细胞、SOD均低于对照组(P<0. 05),经治疗后,它们比治疗前都有显著提高(P<0. 05),但仍然低于对照组(P<0. 05)。结论:儿童病毒性脑炎继发癫痫患者存在炎性因子表达异常、免疫功能的紊乱及机体氧化应激等现象,奥卡西平治疗可有效治疗病毒性脑炎继发癫痫,并有效降低此类患者的炎性因子水平,有效调节患者的免疫功能紊乱和机体氧化应激状态。Objective:To investigate the effects of oxcarbazepine on the,inflammatory factors,immune function and oxidative stress in children patients with epilepsy secondary to viral encephalitis. Methods: 59 cases of children diagnosed as epilepsy secondary to viral encephalitis were selected for experimental group and 35 healthy subjects were used as control group.The patients with epilepsy secondary to viral encephalitis were treated with Oxcarbazepine tablets for 8 months.The therapeutic effect of oxcarbazepine in the treatment of epilepsy secondary to viral encephalitis was observed and the levels of serum inflammatory factors(IL-1β,IL-8,IL-6 and TNF-α)and the changes in T cell subgroups including CD3^+,CD4^+ and CD8^+ before and after treatment were examined.Besides that,we also observed the influence of oxcarbazepine on oxidative stress indictors(ROS,SOD and MDA). Results: The effective rate of oxcarbazepine in the treatment of epilepsy secondary to viral encephalitis was 83.05%,and oxcarbazepine could treat this kind of disease effectively.IL-8,IL-6,TNF-α,CD8^+T cells,ROS and MDA before treatment were higher than those of control group( P <0.05).These indexes were significantly lower after treatment( P <0.05),but still higher than those of control group( P <0.05).The CD3^+,CD4^+T cells and SOD level were lower than those of the control group.After treatment,they were significantly higher than those of before treatment,but still lower than the control group( P <0.05). Conclusion: The patients with epilepsy secondary to viral encepha-litis have abnormal high level of inflammatory factors,disorders of immune function and oxidative stress.Oxcarbazepine can effectively treat the secondary epilepsy induced by viral encephalitis,and effectively reduce the level of inflammatory factors in such epileptic patients,meanwhile effectively regulate the immune dysfunction and oxidative stress state in the patients with such epilepsy.

关 键 词：奥卡西平 儿童病毒性脑炎 癫痫 疗效 

分 类 号：R741.05[医药卫生—神经病学与精神病学]