Specific function and modulation of teleost monocytes/macrophages: polarization and phagocytosis  

作　　者：Xin-Jiang Lu Jiong Chen 

机构地区：[1]Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Ningbo University, Ningbo Zhejiang 315211, China [2]Key Laboratory of Applied Marine Biotechnology of Ministry of Education, Ningbo University, Ningbo Zhejiang 315211, China

出　　处：《Zoological Research》2019年第3期146-150,共5页动物学研究（英文）

基　　金：supported by the National Natural Science Foundation of China(31772876,41776151);Natural Science Foundation of Zhejiang Province(LZ18C190001,LR18C040001);Scientific Innovation Team Project of Ningbo(2015C110018);K.C.Wong Magna Fund in Ningbo University

摘　　要：Macrophages exist in most tissues and play a variety of functions in vertebrates.Teleost fish species are found in most aquatic environments throughout the world and are quite diverse for a group of vertebrate animals.Due to whole genome duplication and en vironme ntal adaptati on,teleost monocytes/macrophages possess a variety of different functions and modulations compared with those of mammals.A deeper understanding of teleost monocytes/macrophages in the immune system will not only help develop teleost-specific methods of disease prevention but will also help improve our understanding of the various immune mechanisms in mammals.In this review,we summarize the differences in polarizati on and phagocytosis of teleost and mammalian macrophages to improve our understanding of the various immune mechanisms in vertebrates.Macrophages exist in most tissues and play a variety of functions in vertebrates. Teleost fish species are found in most aquatic environments throughout the world and are quite diverse for a group of vertebrate animals. Due to whole genome duplication and environmental adaptation, teleost monocytes/macrophages possess a variety of different functions and modulations compared with those of mammals.A deeper understanding of teleost monocytes/macrophages in the immune system will not only help develop teleost-specific methods of disease prevention but will also help improve our understanding of the various immune mechanisms in mammals. In this review, we summarize the differences in polarization and phagocytosis of teleost and mammalian macrophages to improve our understanding of the various immune mechanisms in vertebrates.

关 键 词：TELEOST Monocytes/Macrophages PHAGOCYTOSIS CYTOKINE producti on Comparative IMMUNOLOGY 

分 类 号：Q[生物学]