新辅助化疗结合放疗与单纯放疗治疗局部晚期宫颈癌的临床效果比较  

Comparison of clinical effects of neoadjuvant chemotherapy combined with radiotherapy and single radiotherapy in treatment of locally advanced cervical cancer

作　　者：吴晓翠[1] 魏利[1] 王跃伟[1] 李会荣[1] 李白羽[1] 刘明博[1] WU Xiaocui;WEI Li;WANG Yuewei;LI Huirong;LI Baiyu;LIU Mingbo(Henan Provincial People’s Hospital,Zhengzhou 450000 Henan,China)

机构地区：[1]河南省人民医院,河南郑州450000

出　　处：《中国民康医学》2019年第7期12-14,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:比较新辅助化疗结合放疗与单纯放疗治疗局部晚期宫颈癌的临床效果。方法:选择80例局部晚期宫颈癌患者作为观察对象。采用随机数字表法将其分为观察组和对照组各40例。对照组给予单纯放疗治疗,观察组在对照组基础上给予新辅助化疗。比较两组治疗总缓解率、治疗前后组织病理学分期、肿瘤直径及不良反应发生率。结果:观察组治疗总缓解率为80.0%,明显高于对照组的57.5%,差异有统计学意义(P<0.05)。治疗后,观察组组织病理学状况明显优于对照组,肿瘤直径明显小于对照组,差异有统计学意义(P<0.05)。两组患者恶心、呕吐、腹泻、中性粒细胞减少、贫血、血小板减少及肝功能异常发生率比较,差异均无统计学意义(P>0.05)。结论:新辅助化疗结合放疗治疗局部晚期宫颈癌的效果显著,可改善病灶的组织病理学分级,缩小肿瘤直径,且未增加不良反应。Objective:To compare clinical effects of neoadjuvant chemotherapy combined with radiotherapy and single radiotherapy in treatment of locally advanced cervical cancer.Methods:80 patients with locally advanced cervical cancer were selected as the observation subjects,and were divided into observation group(n=40)and control group(n=40)by using the random number table method.The control group received radiotherapy alone,while the observation group received neoadjuvant chemotherapy on the basis of that of the control group.The total remission rate,the histopathological stage before and after the treatment,the tumor diameter and the incidence of adverse reactions were compared between the two groups.Results:The total remission rate of the observation group was 80.0%,which was significantly higher than that of the control group(57.5%),and the difference was statistically significant(P<0.05).After the treatment,the histopathological status of the observation group was significantly better than that of the control group,the tumor diameter was significantly smaller than that of the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidences of nausea,vomiting,diarrhea,neutropenia,anemia,thrombocytopenia and abnormal liver function between the two groups(P>0.05).Conclusions:Neoadjuvant chemotherapy combined with radiotherapy has a significant effect on locally advanced cervical cancer.Moreover,it can improve the histopathological grade of the lesion and reduce the tumor diameter without increasing the adverse reactions.

关 键 词：新辅助化疗 放疗 局部晚期宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]