左旋芹菜甲素治疗阿尔茨海默症的疗效分析  

Analysis of efficacy of L-apigenin A in the treatment of Alzheimer's disease

作　　者：陈庆华 张凤强 李立新 凌丽 薛文翠 Chen Qinghua;Zhang Fengqiang;Li Lixin;Ling Li;Xue Wencui(Department of Geriatrics, Qinhuangdao Military Hospital, Qinhuangdao Hebei 066000, China)

机构地区：[1]秦皇岛军工医院老年病科,河北省066000

出　　处：《中国基层医药》2019年第10期1182-1184,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：河北省秦皇岛市科技支撑计划项目(201502A104).

摘　　要：目的观察芹菜籽提取物左旋芹菜甲素对阿尔茨海默病(Alzheimer's disease,AD)的治疗作用,分析简明精神状态量表(MMSE)和阿尔茨海默病评估量表认知部分(ADAS-Cog)评分的相关性。方法选取2009年1月至2014年12月在秦皇岛军工医院住院的AD患者34例,采用芹菜籽提取物左旋芹菜甲素进行治疗,评价患者治疗前及治疗后18 d、36 d、72 d的MMSE和ADAS-Cog,分析两者的相关性。结果治疗后72 d的MMSE评分[(22.59±1.13)分]与治疗前[(20.53±1.42)分]、治疗后18 d[(20.44±1.24)分]、36 d[(20.97±1.17)分]比较,差异均有统计学意义(t=6.619、7.473、5.807,均P<0.05);治疗后72 d的ADAS-Cog评分[(17.09±1.53)分]与治疗前[(20.47±2.85)分]、治疗后18 d[(20.18±2.34)分]、36 d[(20.18±2.49)分]比较,差异均有统计学意义(t=6.093、6.445、6.165,均P<0.05);MMSE评分和ADAS-Cog评分经过Pearson相关系数分析显示具有显著负相关(r=-0.259,P=0.000)。结论芹菜籽提取物左旋芹菜甲素能显著改善AD患者的认知功能,MMSE评分和ADAS-Cog评分具有显著负相关性。Objective To evaluate the effects L-apigenin A on Alzheimer's disease(AD), and analyze the correlation between MMSE and ADAS-cog scores. Methods From January 2009 to December 2014, 34 patients with AD were selected in Qinhuangdao Military Industry Hospital.They were treated with celery seed extract L-apigenin.The MMSE scores and ADAS-cog scores were evaluated before treatment and 18, 36 and 72 d after treatment.The correlation between MMSE scores and ADAS-cog scores was analyzed. Results There were statistically significant differences in the MMSE scores between 72d after treatment[(22.59±1.13)points]and before treatment[(20.53±1.42)points], 18d after treatment[(20.44±1.24)points]and 36d after treatment[(20.97±1.17)points](t=6.619, 7.473, 5.807, all P<0.05). There were statistically significant differences in ADAS-Cog scores between 72d after treatment[(17.09±1.53)points]and before treatment[(20.47±2.85)points], 18d after treatment[(20.18±2.34)points]and 36d after treatment[(20.18±2.49)points](t=6.093, 6.445, 6.165, all P<0.05). The MMSE score and ADAS-Cog score had negative correlation by Pearson analysis (r=-0.259, P=0.000). Conclusion L-apigenin A can significantly improve the cognitive function of patients with AD.There is significant negative correlation between the MMSE scores and ADAS-cog scores.

关 键 词：阿尔茨海默病 简明精神病状态评定量表 芹菜素 认知 治疗结果 

分 类 号：R749.16[医药卫生—神经病学与精神病学]