MIF-173位点基因多态性与胃癌易感性的Meta分析  

Association between polymorphism of macrophage migration inhibitory factor gene-173 locus and susceptibility of gastric cancer:A Meta-analysis

作　　者：柯梦 喻学桥[1] 吴琼[1] 吴云华[1] 钱群[1] Ke Meng;Yu Xueqiao;Wu Qiong;Wu Yunhua;Qian Qun(Department of Colorectal and Anal Surgery,Zhongnan Hospital of Wuhan University,Hubei Wuhan 430071,China)

机构地区：[1]武汉大学中南医院结直肠肛门外科,湖北武汉430071

出　　处：《现代肿瘤医学》2019年第12期2125-2129,共5页Journal of Modern Oncology

摘　　要：目的:探讨胃癌与巨噬细胞迁移抑制因子(macrophage migration inhibitory factor,MIF)基因173位点基因多态性之间风险的相关性。方法:计算机检索Embase、Cochrane、PubMed、中国生物医学文献数据库、中国知网、维普及万方数据库,检索时间截止至2018年3月4日。收集胃癌的发生发展与MIF-173位点基因多态性的病例-对照研究。依据纳入标准和排除标准,由2名收集者独立获取文献,提取数据并予以评价其质量。RevMan 5.3软件进行系统分析。结果:一共有4个病例-对照研究被纳入研究中,其中有1 014例患者和1 236例对照者。系统分析最终结果显示,在3个遗传模型中MIF基因173位点单核苷酸多态性与胃癌易感性的相关性差异具有统计学意义[显性遗传模型CC+GC vs GG:OR=1.24,95%CI:1.04～1.47;隐性遗传模型CC vs GC+GG:OR=1.84,95%CI:1.15～2.95;共显性遗传模型CC vs GG:OR=1.87,95%CI:1.34～2.59],在共显性遗传模型GC vs GG中,两者差异无统计学意义(OR=1.12,95%CI:0.94～1.35)。结论:MIF-173位点单核苷酸多态性与胃癌易感性明显相关,基因型CC+GC和CC会加大胃癌发生的风险。Objective:To explore the correlation between macrophage migration inhibitory factor(MIF) 173 C/G polymorphism and risks of gastric cancer.Methods:We searched Embase,Cochrane,PubMed,CBM,CNKI,VIP and WanFang database,until Mar.4 th,2018.Document was acquired independently by the two collectors according to inclusion and exclusion criteria.System analysis was performed by RevMan 5.3 software.Results:A total of four case-control studies were included in the study,including 1 014 patients and 1 236 controls.There was a significant correlation between susceptibility of gastric cancer and the MIF-173 single nucleotide polymorphism[CC+GC vs GG:OR=1.24,95%CI:1.04~1.47,CC vs GC+GG: OR=1.84,95%CI:1.15~2.95,CC vs GG:OR=1.87,95%CI:1.34~2.59].However,there was no significant association between MIF 173 C/G polymorphism and the risk of gastric cancer in GC vs GG models(OR=1.12,95%CI:0.94~1.35).Conclusion:MIF 173 C/G polymorphism is associated with the susceptibility of gastric cancer and genotype CC+GC and CC can increase the risks of suffering from gastric cancer.

关 键 词：巨噬细胞迁移抑制因子 胃癌 基因多态性 病例-对照研究 META分析 

分 类 号：R735.2[医药卫生—肿瘤]