红细胞分布宽度对根治性直肠癌切除术后预后评估的价值研究  

Prognostic significance of preoperative red cell distribution width in patients who underwent radical rectal cancer resection

作　　者：刘晨 陈子璐 吴云桦 郑见宝[1] 魏光兵[1] 高琪 孙学军[1] Liu Chen;Chen Zilu;Wu Yunhua;Zheng Jianbao;Wei Guangbing;Gao Qi;Sun Xuejun(Department of General Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;Department of Neonatal Surgery,Xi'an Children's Hospital,Shaanxi Xi'an 710003,China)

机构地区：[1]西安交通大学第一附属医院普通外科,陕西西安710061 [2]西安市儿童医院新生儿外科,陕西西安710003

出　　处：《现代肿瘤医学》2019年第12期2130-2133,共4页Journal of Modern Oncology

基　　金：陕西省科学技术研究发展计划项目(编号:2016SF-015);陕西省科技统筹创新工程计划项目(编号:2013KTCQ03-08);西安交通大学基本科研业务费专项科研项目(编号:xjj2018123)

摘　　要：目的:探讨红细胞分布宽度(red cell distribution width,RDW)与恶性直肠癌患者临床病理特征及预后的关系。方法:分析2010年到2013年在西安交通大学第一附属医院普通外科诊断为直肠癌并行根治性直肠癌切除术患者289例,通过收集患者临床病理及预后相关资料,经ROC曲线分析将患者分为高RDW组和低RDW组,比较两组患者术后近远期疗效。结果:不同RDW组别间患者一般资料比较未见统计学差异。而高RDW组患者肿瘤直径较大、肿瘤更易发生淋巴脉管浸润且术前巨噬细胞较高(P<0.05)。高RDW组患者3年总生存率及3年无病生存率均较低RDW组差。进一步通过COX回归分析发现N分期、淋巴脉管浸润、肿瘤分化程度和RDW为根治性直肠癌切除术后患者3年总生存率的独立危险因素。结论:RDW是直肠癌预后的独立危险因素,可作为直肠癌患者预后评估指标之一。Objective:To investigate the relationship between red cell distribution width(RDW) and clinical pathological features,prognosis in malignant rectal cancer patients.Methods:We collected the clinical data of the patients who diagnosed as rectal cancer and underwent radical rectal cancer resection in the department of of general surgery of the First Affiliated Hospital of Xi’an Jiaotong University from 2010 to 2013.These patients were analyzed by the ROC curve and divided into the low RDW group and high RDW group.Then the clinical pathological and prognosis data between two groups were compared.Results:There was no difference in general data between two groups.The patients in the higher RDW group had larger tumor diameter,higher lymph vascular invasion rate and higher preoperative macrophage(P<0.05).The high RDW group had worse three years overall survival rate and disease-free survival rate.In the following COX regression analysis,the risk factors for the prognosis of rectal patients included N stage,lymphvascular invasion,tumor differentiated degree and RDW.Conclusion:RDW is an independent risk factor for the prognosis of rectal cancer and can be served as a prognostic index for rectal cancer.

关 键 词：直肠癌 直肠癌根治术 红细胞分布宽度 预后 

分 类 号：R735.37[医药卫生—肿瘤]