DPD、MTHFR和TS表达水平与氟尿嘧啶类药物治疗消化道肿瘤疗效及预后关系的研究进展  

Advances in the efficacy and prognosis of DPD,MTHFR and TS in the application of fluorouracil in gastrointestinal cancer

作　　者：吴沛鸿 徐玲[1] Wu Peihong;Xu Ling(Department of Medical Oncology,the First Hospital of China Medical University,Liaoning Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院肿瘤内科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2019年第12期2192-2195,共4页Journal of Modern Oncology

基　　金：国家自然科学基金(编号:81673025)

摘　　要：消化道恶性肿瘤包括结直肠癌、胃癌和食管癌等。尽管使用了各种治疗方式,癌症患者仍然有复发和转移。绝大多数患者确诊时即为中晚期,因而化疗在癌症患者中发挥重要作用。作为5-FU抗癌活性中的三个关键酶,二氢嘧啶脱氢酶(DPD)、5,10-亚甲基四氢叶酸还原酶(MTHFR)、胸苷酸合成酶(TS)与消化道肿瘤的疗效、对化疗药物的敏感性及患者的预后有密切关系。Gastrointestinal cancer includes colorectal cancer,gastric cancer and esophageal cancer.Despite the use of various treatments,cancer patients still suffer from the recurrence and metastasis of malignant cells.When the patients are diagnosed,they are almost in the middle and late stage.Therefore,chemotherapy play an important role for the treatment of these patients.As the key enzymes in the anti-cancer activity of 5-FU,dihydropyrimidine dehydrogenase(DPD),5,10-methylenetetrahydrofolate reductase(MTHFR) and thymidylate synthase(TS) are closely related to the therapeutic effect of gastrointestinal cancer,the sensitivity to chemotherapy drugs and the prognosis of the patients.

关 键 词：DPD MTHFR TS 肿瘤 治疗 预后 

分 类 号：R735[医药卫生—肿瘤]