PET-MR与PET-CT显像中不同器官18F-FDG阳性病变SUVmax的比较  

Comparison of SUVmax Between 18F-FDG Positive Lesions in Different Organs of PET-MR and PET-CT Imaging

作　　者：李灿[1] 徐白萱[1] 刘家金[1] 富丽萍[1] LI Can;XU Baixuan;LIU Jiajin;FU Liping(Department of Nuclear Medicine, PLA General Hospital, Beijing 100853,China)

机构地区：[1]解放军总医院核医学科

出　　处：《中国医学影像学杂志》2019年第5期379-384,共6页Chinese Journal of Medical Imaging

摘　　要：目的探讨PET-MR与PET-CT在不同器官部位病变最大标准化摄取值(SUVmax)的差异,评价PET-MRSUVmax对不同器官18F-脱氧葡萄糖(18F-FDG)阳性病变定量诊断的能力。资料与方法回顾性分析以肿瘤相关主诉就诊,且同一天先后接受PET-CT和PET-MR检查的150例患者,两种检查时间间隔25~45min。选取18F-FDG阳性病灶最大层面手动勾画感兴趣区,获得采用PET-MR测得的最大标准化摄取值(SUVmax_MRI)与采用PET-CT测得的最大标准化摄取值(SUVmax_CT),将经病理或临床确诊的18F-FDG阳性病灶分为6组(头颈部、肺部、肝脏、胰腺、胃肠道和骨骼)。分析2个成像系统SUVmax的相关性和一致性。结果纳入6组的112个18F-FDG阳性病灶,分布于头颈部(15例)、肺部(15例)、肝脏(31例)、胰腺(21例)、胃肠道(11例)、骨骼(19例)。6组数据SUVmax_MRI与SUVmax_CT均呈高度正相关(r=0.96、0.97、0.96、0.95、0.94、0.91,P<0.05)。SUVmax_MRI与SUVmax_CT之间,数据最大变异出现在肺部(0.16),其次为头颈部(0.13),其他变异依次为胃肠道(0.11)、肝脏(0.08)、骨骼(0.03)和胰腺(0.02)。结论18F-FDGPET-MR可提供可靠的定量诊断信息用于肿瘤患者的临床评估。但SUVmax数据间最大的差异出现在肺部病变,临床工作中对于肺部病灶定量分析仍需谨慎。Purpose To explore the difference of maximum SUV (SUVmax) of lesions between PET-MR and PET-CT in different organs, and to assess the ability of PET-MR SUVmax to quantitatively diagnose 18F-deoxyglucose (18F-FDG) positive lesions in different organs. Materials and Methods 150 patients who were treated with tumor-associated chief complaint and successively underwent PET-CT and PET-MR examinations on the same day were retrospectively analyzed. The interval between the two examinations was 25 to 45 minutes. 18F-FDG positive lesion with maximum area was opted to manually delineate ROI, and the maximum standardized uptake value (SUVmax_MRI) measured by PET-MR and that (SUVmax_CT) measured by PET-CT were obtained. Pathologically or clinically diagnosed 18F-FDG positive lesions were divided into 6 groups (head and neck, lung, liver, pancreas, gastrointestinal tract and bone). The correlation and consistency of SUVmax of the two imaging systems were analyzed. Results 112 18F-FDG positive lesions of the 6 groups were included in the study. They were distributed in the head and neck (15 cases), lung (15 cases), liver (31 cases), pancreas (21 cases), gastrointestinal tract (11 cases), and bone (19 cases). The SUVmax_MRI and SUVmax_CT in the 6 groups of data were highly correlated (r=0.96, 0.97, 0.96, 0.95, 0.94 and 0.91, respectively, P<0.05). The largest data variability, as compared between the SUVmax_MRI and SUVmax_CT, occurred in the lungs (0.16), followed by the head and neck (0.13), then gastrointestinal tract (0.11), livers (0.08), bone (0.03) and pancreas (0.02). Conclusion 18F-FDG PET-MR provides reliable quantitative diagnostic information for clinical evaluation of cancer patients. However, the biggest difference between the SUVmax data lay in the lung lesions, suggesting that quantitative analysis of lung lesions remains to be a cautious practice in clinic.

关 键 词：肿瘤 正电子发射断层显像术 体层摄影术 X线计算机 磁共振成像 氟脱氧葡萄糖F18 

分 类 号：R73[医药卫生—肿瘤] R445.6[医药卫生—临床医学]