抗NMDA受体脑炎和精神分裂症相关性研究进展  

Advances in research on the relationship between anti-NMDA receptor encephalitis and schizophrenia

作　　者：许委娟[1] 许毅[1] XU Weijuan;XU Yi(Department of Mental Health,First Affiliated Hospital,College of Medicine,Zhejiang University,Zhejiang Key Laboratory of Diagnosis and Treatment of Mental Disorders,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院附属第一医院精神卫生科浙江省精神障碍诊疗和防治技术重点实验室

出　　处：《中国现代医生》2019年第11期165-168,共4页China Modern Doctor

基　　金：浙江省科技厅公益分析测试项目(2016C37076)

摘　　要：精神分裂症病因未完全明确,N-甲基-D-天冬氨酸(N-methyl-D-aspartic acid receptor,NMDA)受体功能不足是精神分裂症的重要发病机制,随着抗NMDA受体脑炎的发现,以及在精神分裂症人群中也发现抗NMDA受体抗体阳性患者,抗NMDA受体抗体阳性可能是精神分裂症某一种亚型。本文旨在总结抗NMDA受体脑炎及精神分裂症之间相关性的研究结果,进一步拓展对精神分裂症的认识、治疗及评估。The etiology of schizophrenia is not completely clear. The lack of N-methyl-D-aspartic acid receptor(NMDA) function is an important pathogenesis of schizophrenia. With the discovery of anti-NMDA receptor encephalitis, as well as anti-NMDA receptor antibody-positive patients in schizophrenia, anti-NMDA receptor antibody positive may be a subtype of schizophrenia. This article aims to summarize the findings of the association between anti-NMDA receptor encephalitis and schizophrenia, and further expand our understanding, treatment and evaluation of schizophrenia.

关 键 词：抗NMDA受体 脑炎 精神分裂症 自身免疫 

分 类 号：R742.9[医药卫生—神经病学与精神病学]