前列地尔联合依达拉奉对急性脑梗死合并高血压患者凝血功能血浆cTnI Hcy PCT水平及神经功能的影响  

Effects of Alprostadil combined with Edaravone on Coagulation Function, Levels of Plasma cTnI Hcy and PCT and Neurological Function in Patients with Acute Cerebral Infarction Complicated with Hypertension

作　　者：李丽 温霞 LI Li;WEN Xia(People's Hospital of Inner Mongolia Autonomous Region, Inner Mongolia Hohhot 010010, China)

机构地区：[1]内蒙古自治区人民医院急诊科

出　　处：《河北医学》2019年第5期787-791,共5页Hebei Medicine

基　　金：内蒙古自治区人民医院院内基金项目,(编号:2016102)

摘　　要：目的:探讨前列地尔联合依达拉奉对急性脑梗死(ACI)合并高血压(EH)患者凝血功能、血浆肌钙蛋白I(cTnI)、同型半胱氨酸(Hcy)、降钙素原(PCT)水平及神经功能的影响。方法:前瞻性研究126例ACI+EH患者随机分组(观察组,n=63例;对照组,n=63例),均给予常规对症基础治疗,对照组给予依达拉奉治疗,观察组基于以上治疗给予前列地尔治疗,观察两组治疗前及治疗14d后的凝血功能指标、血浆cTnI、Hcy和PCT水平和神经功能情况,评估两组不良反应。结果:治疗后,两组患者活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、凝血酶原时间(PT)明显缩短,D-二聚体(DD)、纤维蛋白原(Fib)含量显著下降(P<0.05),两组患者血浆cTnI、Hcy和PCT水平显著降低(P<0.05),两组患者神经功能缺损量表(mNIHSS)评分显著减少(P<0.05),血清S100B水平显著降低(P<0.05),观察组变化幅度显著大于对照组(P<0.05);组间不良反应总发生率对比,差异无统计学意义(P>0.05)。结论:前列地尔联合依达拉奉可有效改善ACI+EH患者的凝血功能,减轻颅脑损伤和神经功能损伤,利于患者预后,临床应用安全、有效。Objective: To explore the effects of alprostadil combined with edaravone on coagulation function, levels of plasma troponin I (cTnI), homocysteine (Hcy) and procalcitonin (PCT) and neurological function in patients with acute cerebral infarction (ACI) complicated with essential hypertension (EH). Methods: 126 patients with ACI+EH were prospectively studied and randomly grouped (observation group, n=63;control group, n=63). All patients were given conventional symptomatic basic treatment, and control group was given edaravone, and observation group was given alprostadil based on above treatment. The coagulation function indexes, levels of plasma cTnI, Hcy and PCT and neurological function were observed in the two groups before treatment and after 14 d of treatment. The adverse reactions of the two groups were evaluated. Results: After treatment, the activated partial thromboplastin time (APTT), thrombin time (TT) and prothrombin time (PT) were significantly shortened, the contents of D-dimer (DD) and fibrinogen (Fib) were significantly decreased (P<0.05), the levels of plasma cTnI, Hcy and P CT were significantly decreased (P<0.05), and the scores of neurological deficit scale (mNIHSS) were significantly decreased (P<0.05) and the levels of serum S100B were significantly decreased in both groups (P<0.05). The change range in the observation group was significantly larger than that in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between groups (P>0.05). Conclusions: Alprostadil combined with edaravone can effectively improve the coagulation function of ACI + EH patients, alleviate craniocerebral injury and neurological function damage, and is beneficial to the prognosis of patients. It is safe and effective in clinical application.

关 键 词：急性脑梗死合并高血压 前列地尔 依达拉奉 凝血功能 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学] R544.1[医药卫生—临床医学]