Klinefelter综合征伴糖尿病4例及相关文献复习  

Klinefelter syndrome complicated with diabetes mellitus: a report of 4 cases and literature review

作　　者：冯毅[1] 刘宝英[1] Feng Yi;Liu Baoying(Department of Endocrinology, Zhongshan People's Hospital, Zhongshan 528403, China)

机构地区：[1]中山市人民医院内分泌科,528403

出　　处：《国际医药卫生导报》2019年第9期1459-1461,共3页International Medicine and Health Guidance News

摘　　要：目的回顾性分析本院自2016年以来收治的4例Klinefelter综合征(KS)伴糖尿病患者的临床资料,以期提高对本病的认识。方法根据住院及门诊就诊记录,汇总4例KS合并糖尿病患者的病史资料及实验室检查结果并分析。结果4例患者年龄(43.0±12.7)岁,KS确诊年龄(41.5±13.9)岁,身高(1.67±0.07)m,体质指数(BMI)为(22.05±1.87)kg/m2,经治疗后患者血糖及性激素水平明显好转(P<0.05),血脂紊乱无改善(P>0.05)。结论临床上KS早期诊断率低,已婚的成年男性不育是诊断KS的重要线索。KS合并糖尿病除控制血糖及雄激素替代治疗外,应积极处理血脂紊乱、脂肪肝等危险因素。Objective The clinical data of 4 cases of Klinefelter syndrome (KS) complicated with diabetes mellitus admitted to our hospital since 2016 were retrospectively analyzed in order to improve the understanding of the disease. Methods According to the records of inpatient and outpatient visits, the medical history and laboratory examination results of 4 KS patients with diabetes mellitus were summarized and analyzed. Results They were (43.0±12.7) years old, and were diagnosed with KS when they were (41.5 ± 13.9) years old. They were (1.67 ± 0.07) m tall. Their body mass index (BMI) was (22.05 ± 1.87) kg/m2. After the treatment, they got significant improvement in blood glucose and sex hormone levels (P < 0.05), but not in blood lipid disorders (P > 0.05). Conclusion Clinically, the early diagnosis rate of KS is low. Married adult male with infertility is an important clue for the diagnosis of KS. In addition to controlling blood glucose and androgen replacement therapy, risk factors such as dyslipidemia and fatty liver should be actively dealt with in KS patients with diabetes mellitus.

关 键 词：KLINEFELTER综合征 糖尿病 核型 

分 类 号：R697.2[医药卫生—泌尿科学] R587.1[医药卫生—外科学]